FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327899660> ?p ?o ?g. }

• W4327899660 endingPage "853" @default.
• W4327899660 startingPage "848" @default.
• W4327899660 abstract "Despite the immunogenic nature of many ovarian tumors, treatment with immune checkpoint therapies has not led to substantial improvements in ovarian cancer survival. To advance population-level research on the ovarian tumor immune microenvironment, it is critical to understand methodologic issues related to measurement of immune cells on tissue microarrays (TMA) using multiplex immunofluorescence (mIF) assays.In two prospective cohorts, we collected formalin-fixed, paraffin-embedded ovarian tumors from 486 cases and created seven TMAs. We measured T cells, including several sub-populations, and immune checkpoint markers on the TMAs using two mIF panels. We used Spearman correlations, Fisher exact tests, and multivariable-adjusted beta-binomial models to evaluate factors related to immune cell measurements in TMA tumor cores.Between-core correlations of intratumoral immune markers ranged from 0.52 to 0.72, with more common markers (e.g., CD3+, CD3+CD8+) having higher correlations. Correlations of immune cell markers between the whole core, tumor area, and stromal area were high (range 0.69-0.97). In multivariable-adjusted models, odds of T-cell positivity were lower in clear cell and mucinous versus type II tumors (ORs, 0.13-0.48) and, for several sub-populations, were lower in older tissue (sample age > 30 versus ≤ 10 years; OR, 0.11-0.32).Overall, high correlations between cores for immune markers measured via mIF support the use of TMAs in studying ovarian tumor immune infiltration, although very old samples may have reduced antigenicity.Future epidemiologic studies should evaluate differences in the tumor immune response by histotype and identify modifiable factors that may alter the tumor immune microenvironment." @default.
• W4327899660 created "2023-03-21" @default.
• W4327899660 creator A5004055647 @default.
• W4327899660 creator A5013310750 @default.
• W4327899660 creator A5024937673 @default.
• W4327899660 creator A5051731200 @default.
• W4327899660 creator A5054091966 @default.
• W4327899660 creator A5060460614 @default.
• W4327899660 creator A5067426136 @default.
• W4327899660 creator A5068795567 @default.
• W4327899660 creator A5074139274 @default.
• W4327899660 creator A5078015467 @default.
• W4327899660 creator A5087129605 @default.
• W4327899660 creator A5089191285 @default.
• W4327899660 date "2023-03-20" @default.
• W4327899660 modified "2023-10-13" @default.
• W4327899660 title "Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies" @default.
• W4327899660 cites W1919063129 @default.
• W4327899660 cites W1978014946 @default.
• W4327899660 cites W2019090872 @default.
• W4327899660 cites W2027726380 @default.
• W4327899660 cites W2036014067 @default.
• W4327899660 cites W2087810003 @default.
• W4327899660 cites W2109416754 @default.
• W4327899660 cites W2165661271 @default.
• W4327899660 cites W2294138865 @default.
• W4327899660 cites W2468052951 @default.
• W4327899660 cites W2584617802 @default.
• W4327899660 cites W2807649309 @default.
• W4327899660 cites W2890671115 @default.
• W4327899660 cites W2892047621 @default.
• W4327899660 cites W2892058240 @default.
• W4327899660 cites W2972526668 @default.
• W4327899660 cites W3022742890 @default.
• W4327899660 cites W3172599325 @default.
• W4327899660 cites W3197511191 @default.
• W4327899660 cites W4221072860 @default.
• W4327899660 cites W4225470068 @default.
• W4327899660 cites W4295309178 @default.
• W4327899660 doi "https://doi.org/10.1158/1055-9965.epi-22-1285" @default.
• W4327899660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36940177" @default.
• W4327899660 hasPublicationYear "2023" @default.
• W4327899660 type Work @default.
• W4327899660 citedByCount "1" @default.
• W4327899660 countsByYear W43278996602023 @default.
• W4327899660 crossrefType "journal-article" @default.
• W4327899660 hasAuthorship W4327899660A5004055647 @default.
• W4327899660 hasAuthorship W4327899660A5013310750 @default.
• W4327899660 hasAuthorship W4327899660A5024937673 @default.
• W4327899660 hasAuthorship W4327899660A5051731200 @default.
• W4327899660 hasAuthorship W4327899660A5054091966 @default.
• W4327899660 hasAuthorship W4327899660A5060460614 @default.
• W4327899660 hasAuthorship W4327899660A5067426136 @default.
• W4327899660 hasAuthorship W4327899660A5068795567 @default.
• W4327899660 hasAuthorship W4327899660A5074139274 @default.
• W4327899660 hasAuthorship W4327899660A5078015467 @default.
• W4327899660 hasAuthorship W4327899660A5087129605 @default.
• W4327899660 hasAuthorship W4327899660A5089191285 @default.
• W4327899660 hasBestOaLocation W43278996602 @default.
• W4327899660 hasConcept C121608353 @default.
• W4327899660 hasConcept C126322002 @default.
• W4327899660 hasConcept C142724271 @default.
• W4327899660 hasConcept C143998085 @default.
• W4327899660 hasConcept C167672396 @default.
• W4327899660 hasConcept C193270364 @default.
• W4327899660 hasConcept C203014093 @default.
• W4327899660 hasConcept C204232928 @default.
• W4327899660 hasConcept C2776107976 @default.
• W4327899660 hasConcept C2780427987 @default.
• W4327899660 hasConcept C71924100 @default.
• W4327899660 hasConcept C86803240 @default.
• W4327899660 hasConcept C8891405 @default.
• W4327899660 hasConceptScore W4327899660C121608353 @default.
• W4327899660 hasConceptScore W4327899660C126322002 @default.
• W4327899660 hasConceptScore W4327899660C142724271 @default.
• W4327899660 hasConceptScore W4327899660C143998085 @default.
• W4327899660 hasConceptScore W4327899660C167672396 @default.
• W4327899660 hasConceptScore W4327899660C193270364 @default.
• W4327899660 hasConceptScore W4327899660C203014093 @default.
• W4327899660 hasConceptScore W4327899660C204232928 @default.
• W4327899660 hasConceptScore W4327899660C2776107976 @default.
• W4327899660 hasConceptScore W4327899660C2780427987 @default.
• W4327899660 hasConceptScore W4327899660C71924100 @default.
• W4327899660 hasConceptScore W4327899660C86803240 @default.
• W4327899660 hasConceptScore W4327899660C8891405 @default.
• W4327899660 hasFunder F4320309360 @default.
• W4327899660 hasFunder F4320332161 @default.
• W4327899660 hasIssue "6" @default.
• W4327899660 hasLocation W43278996601 @default.
• W4327899660 hasLocation W432789966010 @default.
• W4327899660 hasLocation W432789966011 @default.
• W4327899660 hasLocation W432789966012 @default.
• W4327899660 hasLocation W432789966013 @default.
• W4327899660 hasLocation W432789966014 @default.
• W4327899660 hasLocation W432789966015 @default.
• W4327899660 hasLocation W432789966016 @default.
• W4327899660 hasLocation W432789966017 @default.
• W4327899660 hasLocation W432789966018 @default.

• next