FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327900609> ?p ?o ?g. }

• W4327900609 endingPage "211" @default.
• W4327900609 startingPage "207" @default.
• W4327900609 abstract "Poisonings with diethylene glycol are characterized by acute kidney injury and peripheral neuropathy. In animal studies on the toxicities of diethylene glycol and its metabolite diglycolic acid, remarkable differences in susceptibility to acute kidney injury were observed in identically-dosed rats. In those studies, only about 60% showed acute kidney injury, yet all rats with acute kidney injury showed marked diglycolic acid accumulation in tissues, while no diglycolic acid accumulated in rats without injury. Diglycolic acid is taken into renal cells via sodium-dependent dicarboxylate transporters. When sodium-dependent dicarboxylate transporter-1 is inhibited or knocked down in human kidney cells, diglycolic acid uptake and toxicity are reduced. We hypothesize that the variation in sensitivity to tissue diglycolic acid retention and to diethylene glycol/diglycolic acid toxicity is explained by differential expression of sodium-dependent dicarboxylate transporter-1 in rat kidneys.Using kidney tissue from previous studies, we performed rt-PCR analysis of sodium-dependent dicarboxylate transporter-1 mRNA. In those studies, Wistar-Han rats were either gavage with diethylene glycol 6 g/kg every 12 h for 7 days or with single doses of diglycolic acid 300 mg/kg. Kidney tissue was harvested after euthanasia and preserved in formalin. Tissue slices were homogenized and RNA was isolated using an RNAstorm FFPE RNA Isolation Kit. The expression of sodium-dependent dicarboxylate transporter-1 mRNA was compared between groups that showed diglycolic acid accumulation and acute renal injury with those that showed no diglycolic acid accumulation or toxicity.Significantly higher expression of sodium-dependent dicarboxylate transporter-1 mRNA was present in the kidneys of rats with acute kidney injury and diglycolic acid accumulation compared to those in rats that had no diglycolic acid in their kidneys and no acute kidney injury.The likelihood of acute kidney injury after dosing of rats with diethylene glycol or diglycolic acid is linked with an enhanced ability to take up diglycolic acid into renal cells via the sodium-dependent dicarboxylate transporter-1. The variability in diethylene glycol toxicity in humans, as reported in epidemiological studies, may also be linked with differences in tissue uptake of diglycolic acid.Animals with acute kidney injury after exposure to diethylene glycol or diglycolic acid had higher sodium-dependent dicarboxylate transporter-1 expression and greater diglycolic acid accumulation in renal tissues than animals without acute kidney injury." @default.
• W4327900609 created "2023-03-21" @default.
• W4327900609 creator A5025024613 @default.
• W4327900609 creator A5045434274 @default.
• W4327900609 creator A5049989859 @default.
• W4327900609 creator A5067329118 @default.
• W4327900609 date "2023-03-20" @default.
• W4327900609 modified "2023-09-23" @default.
• W4327900609 title "Variable sensitivity to diethylene glycol poisoning is related to differences in the uptake transporter for the toxic metabolite diglycolic acid" @default.
• W4327900609 cites W2006099356 @default.
• W4327900609 cites W2029382139 @default.
• W4327900609 cites W2040175975 @default.
• W4327900609 cites W2043270400 @default.
• W4327900609 cites W2082819736 @default.
• W4327900609 cites W2084507167 @default.
• W4327900609 cites W2094362295 @default.
• W4327900609 cites W2097203974 @default.
• W4327900609 cites W2099906131 @default.
• W4327900609 cites W2107277218 @default.
• W4327900609 cites W2113726437 @default.
• W4327900609 cites W2140595623 @default.
• W4327900609 cites W2146223375 @default.
• W4327900609 cites W2159722100 @default.
• W4327900609 cites W2192080449 @default.
• W4327900609 cites W2572364764 @default.
• W4327900609 cites W2600355866 @default.
• W4327900609 cites W3122134142 @default.
• W4327900609 cites W3184223746 @default.
• W4327900609 cites W4249278818 @default.
• W4327900609 cites W4296207125 @default.
• W4327900609 doi "https://doi.org/10.1080/15563650.2022.2163659" @default.
• W4327900609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36939119" @default.
• W4327900609 hasPublicationYear "2023" @default.
• W4327900609 type Work @default.
• W4327900609 citedByCount "0" @default.
• W4327900609 crossrefType "journal-article" @default.
• W4327900609 hasAuthorship W4327900609A5025024613 @default.
• W4327900609 hasAuthorship W4327900609A5045434274 @default.
• W4327900609 hasAuthorship W4327900609A5049989859 @default.
• W4327900609 hasAuthorship W4327900609A5067329118 @default.
• W4327900609 hasConcept C104317684 @default.
• W4327900609 hasConcept C126322002 @default.
• W4327900609 hasConcept C149011108 @default.
• W4327900609 hasConcept C178790620 @default.
• W4327900609 hasConcept C185592680 @default.
• W4327900609 hasConcept C2777477808 @default.
• W4327900609 hasConcept C2777516009 @default.
• W4327900609 hasConcept C2779136216 @default.
• W4327900609 hasConcept C2780091579 @default.
• W4327900609 hasConcept C29730261 @default.
• W4327900609 hasConcept C537181965 @default.
• W4327900609 hasConcept C55493867 @default.
• W4327900609 hasConcept C71924100 @default.
• W4327900609 hasConcept C86803240 @default.
• W4327900609 hasConcept C98274493 @default.
• W4327900609 hasConceptScore W4327900609C104317684 @default.
• W4327900609 hasConceptScore W4327900609C126322002 @default.
• W4327900609 hasConceptScore W4327900609C149011108 @default.
• W4327900609 hasConceptScore W4327900609C178790620 @default.
• W4327900609 hasConceptScore W4327900609C185592680 @default.
• W4327900609 hasConceptScore W4327900609C2777477808 @default.
• W4327900609 hasConceptScore W4327900609C2777516009 @default.
• W4327900609 hasConceptScore W4327900609C2779136216 @default.
• W4327900609 hasConceptScore W4327900609C2780091579 @default.
• W4327900609 hasConceptScore W4327900609C29730261 @default.
• W4327900609 hasConceptScore W4327900609C537181965 @default.
• W4327900609 hasConceptScore W4327900609C55493867 @default.
• W4327900609 hasConceptScore W4327900609C71924100 @default.
• W4327900609 hasConceptScore W4327900609C86803240 @default.
• W4327900609 hasConceptScore W4327900609C98274493 @default.
• W4327900609 hasFunder F4320310101 @default.
• W4327900609 hasIssue "4" @default.
• W4327900609 hasLocation W43279006091 @default.
• W4327900609 hasLocation W43279006092 @default.
• W4327900609 hasOpenAccess W4327900609 @default.
• W4327900609 hasPrimaryLocation W43279006091 @default.
• W4327900609 hasRelatedWork W2023487034 @default.
• W4327900609 hasRelatedWork W2075012981 @default.
• W4327900609 hasRelatedWork W2098694955 @default.
• W4327900609 hasRelatedWork W2112727823 @default.
• W4327900609 hasRelatedWork W2158093876 @default.
• W4327900609 hasRelatedWork W2159722100 @default.
• W4327900609 hasRelatedWork W2188520041 @default.
• W4327900609 hasRelatedWork W2336887693 @default.
• W4327900609 hasRelatedWork W2886148610 @default.
• W4327900609 hasRelatedWork W2785926487 @default.
• W4327900609 hasVolume "61" @default.
• W4327900609 isParatext "false" @default.
• W4327900609 isRetracted "false" @default.
• W4327900609 workType "article" @default.