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- W4327905879 abstract "The CNS critically relies on the formation and proper function of its vasculature during development, adult homeostasis and disease. Angiogenesis — the formation of new blood vessels — is highly active during brain development, enters almost complete quiescence in the healthy adult brain and is reactivated in vascular-dependent brain pathologies such as brain vascular malformations and brain tumours. Despite major advances in the understanding of the cellular and molecular mechanisms driving angiogenesis in peripheral tissues, developmental signalling pathways orchestrating angiogenic processes in the healthy and the diseased CNS remain incompletely understood. Molecular signalling pathways of the ‘neurovascular link’ defining common mechanisms of nerve and vessel wiring have emerged as crucial regulators of peripheral vascular growth, but their relevance for angiogenesis in brain development and disease remains largely unexplored. Here we review the current knowledge of general and CNS-specific mechanisms of angiogenesis during brain development and in brain vascular malformations and brain tumours, including how key molecular signalling pathways are reactivated in vascular-dependent diseases. We also discuss how these topics can be studied in the single-cell multi-omics era. The CNS critically relies on an extensive and complex vasculature to function properly. In this Review, Wälchli and colleagues examine the general and CNS-specific mechanisms that underlie angiogenesis in brain development, brain vascular malformations and brain tumours." @default.
- W4327905879 created "2023-03-21" @default.
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- W4327905879 creator A5047152113 @default.
- W4327905879 creator A5072584423 @default.
- W4327905879 date "2023-03-20" @default.
- W4327905879 modified "2023-09-30" @default.
- W4327905879 title "Shaping the brain vasculature in development and disease in the single-cell era" @default.
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