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- W4327909521 abstract "Abstract Background: Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by fibroblast activation and vascular and immune cell dysfunction. Autophagy-related genes are speculated to be involved in the development of SSc. However, the involvement of autophagy-related genes in SSc remains unexplored. This study aimed to explore the explicit mechanism of autophagy in SSc using bioinformatics analysis. Methods: GSE76885 and GSE95065 datasets were downloaded from the Gene Expression Omnibus database, and human autophagy genes were acquired from GeneCards. Following this, 12 autophagy-related differentially expressed genes (autophagy-related DEGs) were obtained using the Venn package of R software. The Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway enrichments and Gene Set Enrichment Analysis were performed to annotate the biological function of autophagy-related DEGs. Receiver operating characteristic (ROC) analyses were performed to explore the diagnostic value of Autophagy-related DEGs in SSc. Finally, regulatory network analysis and single-sample Gene-set Enrichment Analysis (ssGSEA) were performed. Results: A total of 12 autophagy-related DEGs were identified related to the pathogenesis of SSc. Enrichment analysis identified that metabolism-related pathways were remarkably enriched along with classical PI3K/AKT signaling. ROC curve analysis showed that CD93 (AUC = 0.904, P < 0.001) and SFRP4 (AUC = 0.944, P < 0.001) could serve as reliable biomarkers in the diagnosis and treatment of SSc. Regulatory networks analysis identified 126 transcription factors, 93 miRNA molecules and 106 drugs or molecular compounds related to Autophagy-related DEGs. Finally, ssGSEA demonstrated that Autophagy-related DEGs were mainly associated with CCR, macrophages, Treg cells and Type I IFN Response. Conclusion: We identified CD93 and SFRP4 as valuable diagnosis biomarkers for SSc. Moreover, autophagy-related DEGs could affect the development of SSc through autophagy-related pathways, metabolic processes and immune cell infiltration." @default.
- W4327909521 created "2023-03-21" @default.
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- W4327909521 date "2023-03-20" @default.
- W4327909521 modified "2023-10-16" @default.
- W4327909521 title "Identification of Key Autophagy-related Genes and Potential Mechanisms in Systemic Sclerosis" @default.
- W4327909521 doi "https://doi.org/10.21203/rs.3.rs-2663954/v1" @default.
- W4327909521 hasPublicationYear "2023" @default.
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