FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327916682> ?p ?o ?g. }

• W4327916682 abstract "Abstract Background Major depression (MDD) and bipolar disorder (BD) are linked to immune activation, increased oxidative stress, and lower antioxidant defenses. Objectives To systematically review and meta-analyze all data concerning biomarkers of reverse cholesterol transport (RCT), lipid-associated antioxidants, lipid peroxidation products, and autoimmune responses to oxidatively modified lipid epitopes in MDD and BD. Methods Databases including PubMed, Google scholar and SciFinder were searched to identify eligible studies from inception to January 10th, 2023. Guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results The current meta-analysis included 176 studies (60 BD and 116 MDD) and examined 34,051 participants, namely 17,094 with affective disorders and 16,957 healthy controls. Patients with MDD and BD showed a) significantly decreases in RCT (mainly lowered high-density lipoprotein cholesterol and paraoxonase 1); b) lowered lipid soluble vitamins (including vitamin A, D, and coenzyme Q10); c) increased lipid peroxidation and aldehyde formation, mainly increased malondialdehyde (MDA), 4-hydroxynonenal, peroxides, and 8-isoprostanes; and d) Immunoglobulin (Ig)G responses to oxidized low-density lipoprotein and IgM responses to MDA. The ratio of all lipid peroxidation biomarkers / all lipid-associated antioxidant defenses was significantly increased in MDD (standardized mean difference or SMD=0.433; 95% confidence intervals (CI): 0.312; 0.554) and BD (SMD=0.653; CI: 0.501-0.806). This ratio was significantly greater in BD than MDD (p=0.027). Conclusion In MDD/BD, lowered RCT, a key antioxidant and anti-inflammatory pathway, may drive increased lipid peroxidation, aldehyde formation, and autoimmune responses to oxidative specific epitopes, which all together cause increased immune-inflammatory responses and neurotoxicity." @default.
• W4327916682 created "2023-03-21" @default.
• W4327916682 creator A5000646126 @default.
• W4327916682 creator A5002270558 @default.
• W4327916682 creator A5012497158 @default.
• W4327916682 creator A5078636630 @default.
• W4327916682 creator A5081924790 @default.
• W4327916682 creator A5087385754 @default.
• W4327916682 date "2023-03-20" @default.
• W4327916682 modified "2023-09-24" @default.
• W4327916682 title "Reverse cholesterol transport and lipid peroxidation biomarkers in major depression and bipolar disorder: a systematic review and meta-analysis" @default.
• W4327916682 cites W1573392996 @default.
• W4327916682 cites W1955944566 @default.
• W4327916682 cites W1964477960 @default.
• W4327916682 cites W1985538633 @default.
• W4327916682 cites W1989957948 @default.
• W4327916682 cites W1990724076 @default.
• W4327916682 cites W2008971294 @default.
• W4327916682 cites W2010103733 @default.
• W4327916682 cites W2011455317 @default.
• W4327916682 cites W2011854518 @default.
• W4327916682 cites W2013247338 @default.
• W4327916682 cites W2014824398 @default.
• W4327916682 cites W2016056242 @default.
• W4327916682 cites W2016487797 @default.
• W4327916682 cites W2023056790 @default.
• W4327916682 cites W2026297232 @default.
• W4327916682 cites W2026304182 @default.
• W4327916682 cites W2035618047 @default.
• W4327916682 cites W2037168678 @default.
• W4327916682 cites W2041055523 @default.
• W4327916682 cites W2042815338 @default.
• W4327916682 cites W2044390612 @default.
• W4327916682 cites W2050656144 @default.
• W4327916682 cites W2058096429 @default.
• W4327916682 cites W2058368383 @default.
• W4327916682 cites W2060345189 @default.
• W4327916682 cites W2062447292 @default.
• W4327916682 cites W2062955140 @default.
• W4327916682 cites W2064965507 @default.
• W4327916682 cites W2067927862 @default.
• W4327916682 cites W2073131735 @default.
• W4327916682 cites W2082204059 @default.
• W4327916682 cites W2084313555 @default.
• W4327916682 cites W2084947835 @default.
• W4327916682 cites W2090999800 @default.
• W4327916682 cites W2094609169 @default.
• W4327916682 cites W2100145356 @default.
• W4327916682 cites W2100342973 @default.
• W4327916682 cites W2105160377 @default.
• W4327916682 cites W2111022101 @default.
• W4327916682 cites W2120423982 @default.
• W4327916682 cites W2122483352 @default.
• W4327916682 cites W2138187317 @default.
• W4327916682 cites W2142876888 @default.
• W4327916682 cites W2143967889 @default.
• W4327916682 cites W2149248302 @default.
• W4327916682 cites W2169720699 @default.
• W4327916682 cites W2200296684 @default.
• W4327916682 cites W2346699692 @default.
• W4327916682 cites W2506147233 @default.
• W4327916682 cites W2608277613 @default.
• W4327916682 cites W2766569620 @default.
• W4327916682 cites W2796284997 @default.
• W4327916682 cites W2890089114 @default.
• W4327916682 cites W2905060458 @default.
• W4327916682 cites W2907139974 @default.
• W4327916682 cites W2944128273 @default.
• W4327916682 cites W2953536521 @default.
• W4327916682 cites W2964036664 @default.
• W4327916682 cites W2965420943 @default.
• W4327916682 cites W2966182111 @default.
• W4327916682 cites W2969462995 @default.
• W4327916682 cites W2976364353 @default.
• W4327916682 cites W3003041181 @default.
• W4327916682 cites W3011644990 @default.
• W4327916682 cites W3031123317 @default.
• W4327916682 cites W3036823882 @default.
• W4327916682 cites W3048936470 @default.
• W4327916682 cites W3089171936 @default.
• W4327916682 cites W3093022522 @default.
• W4327916682 cites W3098774177 @default.
• W4327916682 cites W3118620774 @default.
• W4327916682 cites W3118737150 @default.
• W4327916682 cites W3134899986 @default.
• W4327916682 cites W3135384619 @default.
• W4327916682 cites W3148962211 @default.
• W4327916682 cites W3149435916 @default.
• W4327916682 cites W3153099895 @default.
• W4327916682 cites W3186663430 @default.
• W4327916682 cites W3194683897 @default.
• W4327916682 cites W4226075339 @default.
• W4327916682 cites W4226084468 @default.
• W4327916682 cites W4226094208 @default.
• W4327916682 cites W4247088117 @default.
• W4327916682 cites W4285492995 @default.
• W4327916682 cites W4286251921 @default.
• W4327916682 cites W4290420467 @default.
• W4327916682 cites W4294243416 @default.
• W4327916682 cites W4299627282 @default.

• next