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- W4327932008 abstract "Introduction Platelets mediate adhesion and aggregation via membrane glycoproteins. The glycoprotein (GP)IIbIIIa binds to fibrinogen and other matrix proteins. Recently we observed platelets, forming long, thin membrane protrusions (tethers) that were enriched with GPIIbIIIa in some patients ([Fig.1]). These tethers are very similar to Platelet-derived Integrin & Tetraspanin-rich Tethers (PITTs) described in mouse models [1]. The clinical implications of these tethers remain unclear. We assessed the frequency of this finding in patients with myeloproliferative neoplasms (MPN). MPN are associated with an increased risk for thrombotic complications." @default.
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- W4327932008 date "2023-02-01" @default.
- W4327932008 modified "2023-10-10" @default.
- W4327932008 title "Platelet GPIIbIIIa enriched membrane protrusions (Tether) in healthy and diseased individuals" @default.
- W4327932008 cites W2022755299 @default.
- W4327932008 doi "https://doi.org/10.1055/s-0042-1760611" @default.
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