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- W4327948846 abstract "Nuclear receptor coregulators are the principal regulators of Estrogen Receptor (ER)-mediated transcription. ERβ, an ER subtype first identified in 1996, is associated with poor outcomes in breast cancer (BCa) subtypes, and the coexpression of the ERβ1 isoform and AIB-1 and TIF-2 coactivators in BCa-associated myofibroblasts is associated with high-grade BCa. We aimed to identify the specific coactivators that are involved in the progression of ERβ-expressing BCa. ERβ isoforms, coactivators, and prognostic markers were tested using standard immunohistochemistry. AIB-1, TIF-2, NF-kB, p-c-Jun, and/or cyclin D1 were differentially correlated with ERβ isoform expression in the BCa subtypes and subgroups. The coexpression of the ERβ5 and/or ERβ1 isoforms and the coactivators were found to be correlated with a high expression of P53, Ki-67, and Her2/neu and large-sized and/or high-grade tumors in BCa. Our study supports the notion that ERβ isoforms and coactivators seemingly coregulate the proliferation and progression of BCa and may provide insight into the potential therapeutic uses of the coactivators in BCa." @default.
- W4327948846 created "2023-03-21" @default.
- W4327948846 creator A5039165663 @default.
- W4327948846 creator A5065244614 @default.
- W4327948846 date "2023-03-17" @default.
- W4327948846 modified "2023-09-25" @default.
- W4327948846 title "Significant Association of Estrogen Receptor-β Isoforms and Coactivators in Breast Cancer Subtypes" @default.
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- W4327948846 doi "https://doi.org/10.3390/cimb45030166" @default.
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- W4327948846 hasPublicationYear "2023" @default.
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