Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327956448> ?p ?o ?g. }
- W4327956448 endingPage "5861" @default.
- W4327956448 startingPage "5861" @default.
- W4327956448 abstract "Plant bacterial diseases are an intractable problem due to the fact that phytopathogens have acquired strong resistances for traditional pesticides, resulting in restricting the quality and yield of agricultural products around the world. To develop new agrochemical alternatives, we prepared a novel series of sulfanilamide derivatives containing piperidine fragments and assessed their antibacterial potency. The bioassay results revealed that most molecules displayed excellent in vitro antibacterial potency towards Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac). In particular, molecule C4 exhibited outstanding inhibitory activity toward Xoo with EC50 value of 2.02 µg mL−1, which was significantly better than those of the commercial agents bismerthiazol (EC50 = 42.38 µg mL−1) and thiodiazole copper (EC50 = 64.50 µg mL−1). A series of biochemical assays confirmed that compound C4 interacted with dihydropteroate synthase, and irreversibly damaged the cell membrane. In vivo assays showed that the molecule C4 presented acceptable curative and protection activities of 34.78% and 39.83%, respectively, at 200 µg mL−1, which were greater than those of thiodiazole and bismerthiazol. This study highlights the valuable insights for the excavation and development of new bactericides that can concurrently target dihydropteroate synthase and bacterial cell membranes." @default.
- W4327956448 created "2023-03-21" @default.
- W4327956448 creator A5015824153 @default.
- W4327956448 creator A5048963877 @default.
- W4327956448 creator A5050060219 @default.
- W4327956448 creator A5066401817 @default.
- W4327956448 creator A5070761099 @default.
- W4327956448 creator A5071119196 @default.
- W4327956448 creator A5080399881 @default.
- W4327956448 creator A5091645862 @default.
- W4327956448 date "2023-03-20" @default.
- W4327956448 modified "2023-10-14" @default.
- W4327956448 title "Novel Sulfonamide Derivatives Containing a Piperidine Moiety as New Bactericide Leads for Managing Plant Bacterial Diseases" @default.
- W4327956448 cites W108261619 @default.
- W4327956448 cites W1915578613 @default.
- W4327956448 cites W2000715893 @default.
- W4327956448 cites W2008899936 @default.
- W4327956448 cites W2019716999 @default.
- W4327956448 cites W2021086426 @default.
- W4327956448 cites W2047409754 @default.
- W4327956448 cites W2059738917 @default.
- W4327956448 cites W2064100312 @default.
- W4327956448 cites W2074948884 @default.
- W4327956448 cites W2091590599 @default.
- W4327956448 cites W2097524602 @default.
- W4327956448 cites W2098567697 @default.
- W4327956448 cites W2100952570 @default.
- W4327956448 cites W2104249814 @default.
- W4327956448 cites W2111226154 @default.
- W4327956448 cites W2128635872 @default.
- W4327956448 cites W2152433359 @default.
- W4327956448 cites W2286942279 @default.
- W4327956448 cites W2310063671 @default.
- W4327956448 cites W2311774742 @default.
- W4327956448 cites W2407040666 @default.
- W4327956448 cites W2584955680 @default.
- W4327956448 cites W2743256583 @default.
- W4327956448 cites W2763272955 @default.
- W4327956448 cites W2886797471 @default.
- W4327956448 cites W2947160532 @default.
- W4327956448 cites W2949786840 @default.
- W4327956448 cites W2997868174 @default.
- W4327956448 cites W3002062820 @default.
- W4327956448 cites W3012404186 @default.
- W4327956448 cites W3014241423 @default.
- W4327956448 cites W3019321279 @default.
- W4327956448 cites W3033972816 @default.
- W4327956448 cites W3044031396 @default.
- W4327956448 cites W3092113203 @default.
- W4327956448 cites W3094427961 @default.
- W4327956448 cites W3099156655 @default.
- W4327956448 cites W3110970137 @default.
- W4327956448 cites W3143531820 @default.
- W4327956448 cites W3156425033 @default.
- W4327956448 cites W3167757037 @default.
- W4327956448 cites W3210030814 @default.
- W4327956448 cites W4200251225 @default.
- W4327956448 cites W4200529140 @default.
- W4327956448 cites W4212962617 @default.
- W4327956448 cites W4293247451 @default.
- W4327956448 cites W4298087697 @default.
- W4327956448 cites W4302307363 @default.
- W4327956448 cites W4304128540 @default.
- W4327956448 cites W4312085313 @default.
- W4327956448 doi "https://doi.org/10.3390/ijms24065861" @default.
- W4327956448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36982936" @default.
- W4327956448 hasPublicationYear "2023" @default.
- W4327956448 type Work @default.
- W4327956448 citedByCount "1" @default.
- W4327956448 countsByYear W43279564482023 @default.
- W4327956448 crossrefType "journal-article" @default.
- W4327956448 hasAuthorship W4327956448A5015824153 @default.
- W4327956448 hasAuthorship W4327956448A5048963877 @default.
- W4327956448 hasAuthorship W4327956448A5050060219 @default.
- W4327956448 hasAuthorship W4327956448A5066401817 @default.
- W4327956448 hasAuthorship W4327956448A5070761099 @default.
- W4327956448 hasAuthorship W4327956448A5071119196 @default.
- W4327956448 hasAuthorship W4327956448A5080399881 @default.
- W4327956448 hasAuthorship W4327956448A5091645862 @default.
- W4327956448 hasBestOaLocation W43279564481 @default.
- W4327956448 hasConcept C104317684 @default.
- W4327956448 hasConcept C104488531 @default.
- W4327956448 hasConcept C185592680 @default.
- W4327956448 hasConcept C202751555 @default.
- W4327956448 hasConcept C203014093 @default.
- W4327956448 hasConcept C2776568683 @default.
- W4327956448 hasConcept C2776964914 @default.
- W4327956448 hasConcept C2777035104 @default.
- W4327956448 hasConcept C2777234095 @default.
- W4327956448 hasConcept C2778048844 @default.
- W4327956448 hasConcept C2778371730 @default.
- W4327956448 hasConcept C2780746887 @default.
- W4327956448 hasConcept C2781462491 @default.
- W4327956448 hasConcept C54355233 @default.
- W4327956448 hasConcept C55493867 @default.
- W4327956448 hasConcept C57992300 @default.
- W4327956448 hasConcept C71240020 @default.
- W4327956448 hasConcept C86803240 @default.