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- W4327960014 abstract "Dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, has been widely used in treatment of diabetic nephropathy (DN). Previous studies have shown that it has both glucose-lowering effects and renoprotective functions in DN. Tubulointerstitial fibrosis plays an important role in the pathogenesis of development and progression of DN. Angiotensin‑converting enzyme 2 (ACE2), a major component of renin-angiotensin system (RAS), plays an important part in tubulointerstitial fibrosis. Herein, we investigated whether dapagliflozin could ameliorate high glucose induced epithelial to mesenchymal cell transition (EMT) in human proximal tubular epithelial cells (HK2) and attenuated diabetic rat fibrosis through ACE2." @default.
- W4327960014 created "2023-03-21" @default.
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- W4327960014 date "2023-03-01" @default.
- W4327960014 modified "2023-09-26" @default.
- W4327960014 title "WCN23-0945 SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR, DAPAGLIFLOZIN, AMELIORATES HIGH GLUCOSE INDUCED EMT VIA UPREGULATING ANGIOTENSIN CONVERTING ENZYME 2 IN HK2 CELLS." @default.
- W4327960014 doi "https://doi.org/10.1016/j.ekir.2023.02.505" @default.
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