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- W4327968766 abstract "Secretion of melatonin, a natural hormone whose receptors are present in the ciliary epithelium, displays diurnal variation in the aqueous humor (AH), potentially contributing to the regulation of intraocular pressure. This study aimed to determine the effects of melatonin on AH secretion in porcine ciliary epithelium. The addition of 100 µM melatonin to both sides of the epithelium significantly increased the short-circuit current (Isc) by ~40%. Stromal administration alone had no effect on the Isc, but aqueous application triggered a 40% increase in Isc, similar to that of bilateral application without additive effect. Pre-treatment with niflumic acid abolished melatonin-induced Isc stimulation. More importantly, melatonin stimulated the fluid secretion across the intact ciliary epithelium by ~80% and elicited a sustained increase (~50–60%) in gap junctional permeability between pigmented ciliary epithelial (PE) cells and non-pigmented ciliary epithelial (NPE) cells. The expression of MT3 receptor was found to be >10-fold higher than that of MT1 and MT2 in porcine ciliary epithelium. Aqueous pre-treatment with MT1/MT2 antagonist luzindole failed to inhibit the melatonin-induced Isc response, while MT3 antagonist prazosin pre-treatment abolished the Isc stimulation. We conclude that melatonin facilitates Cl− and fluid movement from PE to NPE cells, thereby stimulating AH secretion via NPE-cell MT3 receptors." @default.
- W4327968766 created "2023-03-21" @default.
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- W4327968766 date "2023-03-17" @default.
- W4327968766 modified "2023-10-14" @default.
- W4327968766 title "Regulation of Aqueous Humor Secretion by Melatonin in Porcine Ciliary Epithelium" @default.
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- W4327968766 doi "https://doi.org/10.3390/ijms24065789" @default.
- W4327968766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36982863" @default.
- W4327968766 hasPublicationYear "2023" @default.
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