FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327977234> ?p ?o ?g. }

• W4327977234 abstract "Natural astaxanthin is a high-value ketone carotenoid mainly derived from Haematococcus pluvialis, which is an excellent antioxidant for human consumption. To study the role of lipids in accumulation of astaxanthin, the H. pluvialis-derived astaxanthin synthesis pathway genes (β-carotene ketolase gene, BKT and β-carotene hydroxylase gene, BCH) and fatty acid elongation gene (mitochondrial trans-2-enoyl-coa reductase gene, MECR) were heterologously co-expressed in C. reinhardtii. Zeaxanthin, the precursor of astaxanthin synthesis, was significantly increased after BKT and BCH were expressed. In contrast, the α-carotene that competes with astaxanthin synthesis for lycopene decreased significantly. This redistribution of carbon flow was conducive to the synthesis of astaxanthin. In addition, the transformant only expressed astaxanthin metabolism related genes (BKT, BCH) would lead to an increase in total lipid, a decrease in monounsaturated fatty acids and an increase in polyunsaturated fatty acids. On this basis, the expression of MECR gene further increased the total lipid, and the relative content of different fatty acids also changed. The astaxanthin content of algal strains transformed with BKT and BCH genes was nearly 50% higher than that of the wild type. On this basis, the astaxanthin content of transformants expressing MECR gene related to long-chain fatty acid synthesis was increased by 227.5%. In this study, an astaxanthin production model similar to H. pluvialis by combining carotenoid metabolism and fatty acid metabolism was constructed in C. reinhardtii. The results suggest that the increase in astaxanthin is indeed linked to the regulation of fatty acid metabolism, and this link may involve the type of fatty acids and the dynamics of astaxanthin ester in cells. The strategy of promoting the synthesis of fatty acids has potential to achieve efficient production of astaxanthin in C. reinhardtii." @default.
• W4327977234 created "2023-03-21" @default.
• W4327977234 creator A5014796475 @default.
• W4327977234 creator A5041372773 @default.
• W4327977234 creator A5064584456 @default.
• W4327977234 creator A5075533939 @default.
• W4327977234 creator A5078128438 @default.
• W4327977234 creator A5087961054 @default.
• W4327977234 date "2023-03-20" @default.
• W4327977234 modified "2023-09-26" @default.
• W4327977234 title "Expression of fatty acid related gene promotes astaxanthin heterologous production in Chlamydomonas reinhardtii" @default.
• W4327977234 cites W136328978 @default.
• W4327977234 cites W1556250793 @default.
• W4327977234 cites W1565527343 @default.
• W4327977234 cites W1986782915 @default.
• W4327977234 cites W2007079184 @default.
• W4327977234 cites W2007831617 @default.
• W4327977234 cites W2011584872 @default.
• W4327977234 cites W2025891358 @default.
• W4327977234 cites W2036301709 @default.
• W4327977234 cites W2066419908 @default.
• W4327977234 cites W2067324394 @default.
• W4327977234 cites W2073888783 @default.
• W4327977234 cites W2076206544 @default.
• W4327977234 cites W2077256425 @default.
• W4327977234 cites W2088664456 @default.
• W4327977234 cites W2093854701 @default.
• W4327977234 cites W2102665304 @default.
• W4327977234 cites W2107859967 @default.
• W4327977234 cites W2115905083 @default.
• W4327977234 cites W2138192175 @default.
• W4327977234 cites W2150383938 @default.
• W4327977234 cites W2151318086 @default.
• W4327977234 cites W2153271274 @default.
• W4327977234 cites W2414341486 @default.
• W4327977234 cites W2461927112 @default.
• W4327977234 cites W2591657700 @default.
• W4327977234 cites W2776832117 @default.
• W4327977234 cites W2948491220 @default.
• W4327977234 cites W3006731570 @default.
• W4327977234 cites W3044040031 @default.
• W4327977234 cites W4281761065 @default.
• W4327977234 doi "https://doi.org/10.3389/fnut.2023.1130065" @default.
• W4327977234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37020810" @default.
• W4327977234 hasPublicationYear "2023" @default.
• W4327977234 type Work @default.
• W4327977234 citedByCount "0" @default.
• W4327977234 crossrefType "journal-article" @default.
• W4327977234 hasAuthorship W4327977234A5014796475 @default.
• W4327977234 hasAuthorship W4327977234A5041372773 @default.
• W4327977234 hasAuthorship W4327977234A5064584456 @default.
• W4327977234 hasAuthorship W4327977234A5075533939 @default.
• W4327977234 hasAuthorship W4327977234A5078128438 @default.
• W4327977234 hasAuthorship W4327977234A5087961054 @default.
• W4327977234 hasBestOaLocation W43279772341 @default.
• W4327977234 hasConcept C104317684 @default.
• W4327977234 hasConcept C143065580 @default.
• W4327977234 hasConcept C185592680 @default.
• W4327977234 hasConcept C19038510 @default.
• W4327977234 hasConcept C2776941171 @default.
• W4327977234 hasConcept C2777399995 @default.
• W4327977234 hasConcept C2777727519 @default.
• W4327977234 hasConcept C2780962900 @default.
• W4327977234 hasConcept C28781525 @default.
• W4327977234 hasConcept C543025807 @default.
• W4327977234 hasConcept C55493867 @default.
• W4327977234 hasConcept C86803240 @default.
• W4327977234 hasConceptScore W4327977234C104317684 @default.
• W4327977234 hasConceptScore W4327977234C143065580 @default.
• W4327977234 hasConceptScore W4327977234C185592680 @default.
• W4327977234 hasConceptScore W4327977234C19038510 @default.
• W4327977234 hasConceptScore W4327977234C2776941171 @default.
• W4327977234 hasConceptScore W4327977234C2777399995 @default.
• W4327977234 hasConceptScore W4327977234C2777727519 @default.
• W4327977234 hasConceptScore W4327977234C2780962900 @default.
• W4327977234 hasConceptScore W4327977234C28781525 @default.
• W4327977234 hasConceptScore W4327977234C543025807 @default.
• W4327977234 hasConceptScore W4327977234C55493867 @default.
• W4327977234 hasConceptScore W4327977234C86803240 @default.
• W4327977234 hasLocation W43279772341 @default.
• W4327977234 hasLocation W43279772342 @default.
• W4327977234 hasLocation W43279772343 @default.
• W4327977234 hasOpenAccess W4327977234 @default.
• W4327977234 hasPrimaryLocation W43279772341 @default.
• W4327977234 hasRelatedWork W2007528602 @default.
• W4327977234 hasRelatedWork W2010805526 @default.
• W4327977234 hasRelatedWork W2042312827 @default.
• W4327977234 hasRelatedWork W2069981544 @default.
• W4327977234 hasRelatedWork W2082192693 @default.
• W4327977234 hasRelatedWork W2127834776 @default.
• W4327977234 hasRelatedWork W2362385381 @default.
• W4327977234 hasRelatedWork W2900837785 @default.
• W4327977234 hasRelatedWork W2914128670 @default.
• W4327977234 hasRelatedWork W62197921 @default.
• W4327977234 hasVolume "10" @default.
• W4327977234 isParatext "false" @default.
• W4327977234 isRetracted "false" @default.
• W4327977234 workType "article" @default.