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• W4327977237 abstract "Background Dengue is the most widely distributed arboviral disease in tropical and subtropical countries. Most suspected cases are diagnosed according to the clinical criteria, and early diagnosis is difficult. Moreover, in underdeveloped countries, several factors continue to challenge the diagnosis and surveillance of dengue cases. This study aimed to design a diagnostic algorithm using rapid diagnostic tests (RDTs), ELISA tests, and clinical and hematological variables to confirm dengue cases in febrile patients in Colombia. Methods Altogether, 505 samples were collected. Serum samples were evaluated by RDTs (IgM and IgG antibodies and NS1 antigen), capture IgM and IgG ELISAs, and endpoint hemi-nested RT-PCR assay (qualitative). We statistically analyzed the performance of individual tests to determine the most useful ones to confirm dengue cases accurately. Results Individual results for IgM, IgG, and NS1 RDTs yielded lower sensitivity and specificity values than the reference standard. High sensitivity and specificity were obtained after combining IgM and NS1 ELISA results (96.3% and 96.4%) and NS1 RDT plus IgM ELISA results (90.3% and 96.2%), respectively. Adjusted odds ratios (aORs) were calculated for clinical variables and laboratory tests to differentiate dengue from other febrile illnesses (OFI). This approach showed that myalgia, abdominal tenderness, and platelet count were identified with higher sensitivity to confirm dengue cases. IgM RDT and NS1 RDT differentiated dengue cases from OFI. A positive IgM RDT or a positive NS1 RDT combined with specific signs or symptoms confirmed 81.6% of dengue cases. A combination of clinical findings and a positive NS1 RDT or positive ELISA IgM confirmed 90.6% of the cases. Conclusion Our findings showed that clinical diagnoses in pediatric population alone cannot confirm true dengue cases and needs to be complemented by laboratory diagnostic tests. We also demonstrate the usefulness of combining clinical criteria with RDTs, suggesting that their implementation with the IgM ELISA test improves dengue case confirmation." @default.
• W4327977237 created "2023-03-21" @default.
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• W4327977237 date "2023-03-20" @default.
• W4327977237 modified "2023-10-01" @default.
• W4327977237 title "Improving dengue diagnosis and case confirmation in children by combining rapid diagnostic tests, clinical, and laboratory variables" @default.
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• W4327977237 cites W1965305135 @default.
• W4327977237 cites W1971699048 @default.
• W4327977237 cites W1977473516 @default.
• W4327977237 cites W1988980547 @default.
• W4327977237 cites W1996405663 @default.
• W4327977237 cites W2016833692 @default.
• W4327977237 cites W2028079124 @default.
• W4327977237 cites W2044945592 @default.
• W4327977237 cites W2047933983 @default.
• W4327977237 cites W2048349698 @default.
• W4327977237 cites W2058322328 @default.
• W4327977237 cites W2062107768 @default.
• W4327977237 cites W2067462392 @default.
• W4327977237 cites W2067923663 @default.
• W4327977237 cites W2096003013 @default.
• W4327977237 cites W2105269713 @default.
• W4327977237 cites W2115149563 @default.
• W4327977237 cites W2115306241 @default.
• W4327977237 cites W2121611175 @default.
• W4327977237 cites W2142279567 @default.
• W4327977237 cites W2144900227 @default.
• W4327977237 cites W2165322962 @default.
• W4327977237 cites W2293319368 @default.
• W4327977237 cites W2317458287 @default.
• W4327977237 cites W2330946505 @default.
• W4327977237 cites W2332282872 @default.
• W4327977237 cites W2334731521 @default.
• W4327977237 cites W2346811083 @default.
• W4327977237 cites W2399617559 @default.
• W4327977237 cites W2490739343 @default.
• W4327977237 cites W2512173419 @default.
• W4327977237 cites W2562136678 @default.
• W4327977237 cites W2562700000 @default.
• W4327977237 cites W2587530669 @default.
• W4327977237 cites W2594340443 @default.
• W4327977237 cites W2606996549 @default.
• W4327977237 cites W2607304061 @default.
• W4327977237 cites W2622597846 @default.
• W4327977237 cites W2771726993 @default.
• W4327977237 cites W2772819959 @default.
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• W4327977237 cites W2889297310 @default.
• W4327977237 cites W2892278633 @default.
• W4327977237 cites W2894930875 @default.
• W4327977237 cites W2907948828 @default.
• W4327977237 cites W2921971320 @default.
• W4327977237 cites W2924302306 @default.
• W4327977237 cites W2962773342 @default.
• W4327977237 cites W2966801013 @default.
• W4327977237 cites W2966870404 @default.
• W4327977237 cites W2988321299 @default.
• W4327977237 cites W3000311966 @default.
• W4327977237 cites W3003809264 @default.
• W4327977237 cites W3004942813 @default.
• W4327977237 cites W3005251598 @default.
• W4327977237 cites W3006174098 @default.
• W4327977237 cites W3007512824 @default.
• W4327977237 cites W3011194998 @default.
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• W4327977237 cites W3041813916 @default.
• W4327977237 cites W3045797411 @default.
• W4327977237 cites W3089405925 @default.
• W4327977237 cites W3091670099 @default.
• W4327977237 cites W3099030904 @default.
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• W4327977237 cites W3216020668 @default.
• W4327977237 cites W4211002680 @default.
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• W4327977237 doi "https://doi.org/10.3389/fitd.2023.1118774" @default.
• W4327977237 hasPublicationYear "2023" @default.
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