FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327977252> ?p ?o ?g. }

• W4327977252 abstract "Tissue defects can lead to serious health problems and often require grafts or transplants to repair damaged soft tissues. However, these procedures can be complex and may not always be feasible due to a lack of available tissue. Hydrogels have shown potential as a replacement for tissue grafts due to their ability to support cell survival and encapsulate biomolecules such as growth factors. In particular, guanosine-based hydrogels have been explored as a potential solution, but they often exhibit limited stability which hampers their use in the biofabrication of complex grafts. To address this issue, we explored the use of borate ester chemistry and more complex boric acid derivatives to improve the stability and properties of guanosine-based hydrogels. We hypothesized that the aromatic rings in these derivatives would enhance the stability and printability of the hydrogels through added π-π stack interactions. After optimization, 13 compositions containing either 2-naphthylboronic acid or boric acid were selected. Morphology studies shows a well-defined nanofibrilar structure with good printable properties (thixotropic behaviour, print fidelity and printability). Moreover, the pH of all tested hydrogels was within the range suitable for cell viability (7.4-8.3). Nevertheless, only the boric acid-based formulations were stable for at least 7 days. Thus, our results clearly demonstrated that the presence of additional aromatic rings did actually impair the hydrogel properties. We speculate that this is due to steric hindrance caused by adjacent groups, which disrupt the correct orientation of the aromatic groups required for effective π-π stack interactions of the guanosine building block. Despite this drawback, the developed guanosine-boric acid hydrogel exhibited good thixotropic properties and was able to support cell survival, proliferation, and migration. For instance, SaOS-2 cells planted on these printed structures readily migrated into the hydrogel and showed nearly 100% cell viability after 7 days. In conclusion, our findings highlight the potential of guanosine-boric acid hydrogels as tissue engineering scaffolds that can be readily enhanced with living cells and bioactive molecules. Thus, our work represents a significant advancement towards the development of functionalized guanosine-based hydrogels." @default.
• W4327977252 created "2023-03-21" @default.
• W4327977252 creator A5002191292 @default.
• W4327977252 creator A5003049995 @default.
• W4327977252 creator A5016709266 @default.
• W4327977252 creator A5056308156 @default.
• W4327977252 creator A5063035259 @default.
• W4327977252 creator A5086594378 @default.
• W4327977252 date "2023-03-20" @default.
• W4327977252 modified "2023-10-05" @default.
• W4327977252 title "Optimization of guanosine-based hydrogels with boric acid derivatives for enhanced long-term stability and cell survival" @default.
• W4327977252 cites W1935174685 @default.
• W4327977252 cites W1968918493 @default.
• W4327977252 cites W1998563921 @default.
• W4327977252 cites W2010165954 @default.
• W4327977252 cites W2021194803 @default.
• W4327977252 cites W2031372108 @default.
• W4327977252 cites W2084610464 @default.
• W4327977252 cites W2092860016 @default.
• W4327977252 cites W2096667986 @default.
• W4327977252 cites W2099540110 @default.
• W4327977252 cites W2167279371 @default.
• W4327977252 cites W2188096331 @default.
• W4327977252 cites W2201562456 @default.
• W4327977252 cites W2213504946 @default.
• W4327977252 cites W2294470436 @default.
• W4327977252 cites W2319863978 @default.
• W4327977252 cites W2520718776 @default.
• W4327977252 cites W2528308860 @default.
• W4327977252 cites W2600535362 @default.
• W4327977252 cites W2606251873 @default.
• W4327977252 cites W2737721978 @default.
• W4327977252 cites W2746186558 @default.
• W4327977252 cites W2756259469 @default.
• W4327977252 cites W2764012161 @default.
• W4327977252 cites W2766855696 @default.
• W4327977252 cites W2785241767 @default.
• W4327977252 cites W2788111849 @default.
• W4327977252 cites W2790626628 @default.
• W4327977252 cites W2793827094 @default.
• W4327977252 cites W2887631522 @default.
• W4327977252 cites W2897832052 @default.
• W4327977252 cites W2910734173 @default.
• W4327977252 cites W2914196441 @default.
• W4327977252 cites W2915228344 @default.
• W4327977252 cites W2952142136 @default.
• W4327977252 cites W2966528165 @default.
• W4327977252 cites W3002206259 @default.
• W4327977252 cites W3007102030 @default.
• W4327977252 cites W3007593417 @default.
• W4327977252 cites W3008102423 @default.
• W4327977252 cites W3022870717 @default.
• W4327977252 cites W3041871935 @default.
• W4327977252 cites W3047035572 @default.
• W4327977252 cites W3059605322 @default.
• W4327977252 cites W3081243597 @default.
• W4327977252 cites W3111275026 @default.
• W4327977252 cites W3116337932 @default.
• W4327977252 cites W3138739011 @default.
• W4327977252 cites W3141993092 @default.
• W4327977252 cites W3162747981 @default.
• W4327977252 cites W3163277307 @default.
• W4327977252 cites W3179607730 @default.
• W4327977252 cites W4207047607 @default.
• W4327977252 cites W4290052885 @default.
• W4327977252 cites W4295655086 @default.
• W4327977252 cites W4311665280 @default.
• W4327977252 doi "https://doi.org/10.3389/fbioe.2023.1147943" @default.
• W4327977252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37020512" @default.
• W4327977252 hasPublicationYear "2023" @default.
• W4327977252 type Work @default.
• W4327977252 citedByCount "1" @default.
• W4327977252 countsByYear W43279772522023 @default.
• W4327977252 crossrefType "journal-article" @default.
• W4327977252 hasAuthorship W4327977252A5002191292 @default.
• W4327977252 hasAuthorship W4327977252A5003049995 @default.
• W4327977252 hasAuthorship W4327977252A5016709266 @default.
• W4327977252 hasAuthorship W4327977252A5056308156 @default.
• W4327977252 hasAuthorship W4327977252A5063035259 @default.
• W4327977252 hasAuthorship W4327977252A5086594378 @default.
• W4327977252 hasBestOaLocation W43279772521 @default.
• W4327977252 hasConcept C108586683 @default.
• W4327977252 hasConcept C12554922 @default.
• W4327977252 hasConcept C127413603 @default.
• W4327977252 hasConcept C178790620 @default.
• W4327977252 hasConcept C185592680 @default.
• W4327977252 hasConcept C21951064 @default.
• W4327977252 hasConcept C2776839515 @default.
• W4327977252 hasConcept C2777995097 @default.
• W4327977252 hasConcept C42360764 @default.
• W4327977252 hasConcept C55493867 @default.
• W4327977252 hasConcept C86803240 @default.
• W4327977252 hasConceptScore W4327977252C108586683 @default.
• W4327977252 hasConceptScore W4327977252C12554922 @default.
• W4327977252 hasConceptScore W4327977252C127413603 @default.
• W4327977252 hasConceptScore W4327977252C178790620 @default.
• W4327977252 hasConceptScore W4327977252C185592680 @default.
• W4327977252 hasConceptScore W4327977252C21951064 @default.
• W4327977252 hasConceptScore W4327977252C2776839515 @default.
• W4327977252 hasConceptScore W4327977252C2777995097 @default.

• next