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- W4327980560 abstract "Inflammasomes, composed of the nucleotide-binding oligomerization domain(NOD)-like receptors (NLRs), are immune-functional protein multimers that are closely linked to the host defense mechanism. When NLRs sense pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), they assemble into inflammasomes. Inflammasomes can activate various inflammatory signaling pathways, including nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways, and produce a large number of proinflammatory cytokines, which are closely associated with multiple cancers. They can also accelerate the occurrence and development of cancer by providing suitable tumor microenvironments, promoting tumor cell proliferation, and inhibiting tumor cell apoptosis. Therefore, the exploitation of novel targeted drugs against various inflammasomes and proinflammatory cytokines is a new idea for the treatment of cancer. In recent years, more than 50 natural extracts and synthetic small molecule targeted drugs have been reported to be in the research stage or have been applied to the clinic. Herein, we will overview the mechanisms of inflammasomes in common cancers and discuss the therapeutic prospects of natural extracts and synthetic targeted agents." @default.
- W4327980560 created "2023-03-21" @default.
- W4327980560 creator A5007683979 @default.
- W4327980560 creator A5026577079 @default.
- W4327980560 creator A5050562950 @default.
- W4327980560 creator A5051716075 @default.
- W4327980560 date "2023-03-20" @default.
- W4327980560 modified "2023-10-01" @default.
- W4327980560 title "Mechanism of inflammasomes in cancer and targeted therapies" @default.
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