FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327984579> ?p ?o ?g. }

• W4327984579 endingPage "941" @default.
• W4327984579 startingPage "941" @default.
• W4327984579 abstract "A key feature of an allergic immune response is a T helper type 2 (Th2)-mediated response with production of allergen-specific IgE antibodies. Gardenia jasminoides extract with the crocin removed (GJExCR) has been shown to inhibit IgE-mediated allergic disease. To evaluate the efficacy and mechanism-of-action of this inhibition, GJExCR was used in an ovalbumin (OVA)-induced allergy model in BALB/C mice. Sensitization of BALB/C mice with OVA and aluminum hydroxide was performed on days 1 and 14 by intraperitoneal injection, followed by OVA challenge to the dorsal skin for 2 weeks before removal. Seven days post-challenge, mice were treated with GJExCR topically every day for 11 days. Enzyme-linked immunosorbent assay, flow cytometry analysis, real-time PCR, and western blot were performed to determine IgE and Th2 cytokine levels. Following OVA challenge, Th2 cytokine expression and both total and OVA-specific serum IgE levels increased, of which OVA-specific IgE and Th2 cytokine levels decreased after GJExCR treatment. Flow cytometry analysis revealed that GJExCR treatment decreased CD4+ and CD8+ T cell populations in the spleen and lymph nodes. In addition, treatment with GJExCR downregulated signal transducer and activator of transcription 1 (STAT1) activation and Th2 cytokine levels as compared to control. GJExCR containing geniposide downregulated STAT1 activation in HaCaT cells. These findings demonstrate that GJExCR exerts its anti-allergy effect via inhibition of STAT1 activation, thus regulating the immune response via modulation of Th2 cytokine release and IgE levels. Therefore, we propose GJExCR as a potential treatment for allergic hypersensitivity reactions." @default.
• W4327984579 created "2023-03-21" @default.
• W4327984579 creator A5008045279 @default.
• W4327984579 creator A5017135845 @default.
• W4327984579 creator A5043281038 @default.
• W4327984579 creator A5061782425 @default.
• W4327984579 creator A5070652882 @default.
• W4327984579 creator A5075320521 @default.
• W4327984579 creator A5079152218 @default.
• W4327984579 date "2023-03-20" @default.
• W4327984579 modified "2023-09-26" @default.
• W4327984579 title "Topical Administration of Gardenia jasminoides Extract Regulates Th2 Immunity in OVA-Induced Mice" @default.
• W4327984579 cites W1482121995 @default.
• W4327984579 cites W1853217298 @default.
• W4327984579 cites W1966601696 @default.
• W4327984579 cites W1968068798 @default.
• W4327984579 cites W1972704451 @default.
• W4327984579 cites W1978726038 @default.
• W4327984579 cites W1980596522 @default.
• W4327984579 cites W1998048747 @default.
• W4327984579 cites W2002797131 @default.
• W4327984579 cites W2009993815 @default.
• W4327984579 cites W2022056344 @default.
• W4327984579 cites W2032953083 @default.
• W4327984579 cites W2069654894 @default.
• W4327984579 cites W2074788804 @default.
• W4327984579 cites W2096279219 @default.
• W4327984579 cites W2118329039 @default.
• W4327984579 cites W2123210257 @default.
• W4327984579 cites W2139466919 @default.
• W4327984579 cites W2151808007 @default.
• W4327984579 cites W2301060756 @default.
• W4327984579 cites W2338585871 @default.
• W4327984579 cites W2508049860 @default.
• W4327984579 cites W2582282675 @default.
• W4327984579 cites W2612970755 @default.
• W4327984579 cites W2922127839 @default.
• W4327984579 cites W2948794899 @default.
• W4327984579 cites W2951205992 @default.
• W4327984579 cites W2975912975 @default.
• W4327984579 cites W3094247057 @default.
• W4327984579 cites W3216948422 @default.
• W4327984579 cites W4301015107 @default.
• W4327984579 cites W617782571 @default.
• W4327984579 doi "https://doi.org/10.3390/cells12060941" @default.
• W4327984579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36980282" @default.
• W4327984579 hasPublicationYear "2023" @default.
• W4327984579 type Work @default.
• W4327984579 citedByCount "0" @default.
• W4327984579 crossrefType "journal-article" @default.
• W4327984579 hasAuthorship W4327984579A5008045279 @default.
• W4327984579 hasAuthorship W4327984579A5017135845 @default.
• W4327984579 hasAuthorship W4327984579A5043281038 @default.
• W4327984579 hasAuthorship W4327984579A5061782425 @default.
• W4327984579 hasAuthorship W4327984579A5070652882 @default.
• W4327984579 hasAuthorship W4327984579A5075320521 @default.
• W4327984579 hasAuthorship W4327984579A5079152218 @default.
• W4327984579 hasBestOaLocation W43279845791 @default.
• W4327984579 hasConcept C141105273 @default.
• W4327984579 hasConcept C142724271 @default.
• W4327984579 hasConcept C159654299 @default.
• W4327984579 hasConcept C203014093 @default.
• W4327984579 hasConcept C204787440 @default.
• W4327984579 hasConcept C2776217527 @default.
• W4327984579 hasConcept C2776946954 @default.
• W4327984579 hasConcept C2776953665 @default.
• W4327984579 hasConcept C2777050526 @default.
• W4327984579 hasConcept C2778690821 @default.
• W4327984579 hasConcept C71924100 @default.
• W4327984579 hasConcept C8891405 @default.
• W4327984579 hasConcept C98274493 @default.
• W4327984579 hasConceptScore W4327984579C141105273 @default.
• W4327984579 hasConceptScore W4327984579C142724271 @default.
• W4327984579 hasConceptScore W4327984579C159654299 @default.
• W4327984579 hasConceptScore W4327984579C203014093 @default.
• W4327984579 hasConceptScore W4327984579C204787440 @default.
• W4327984579 hasConceptScore W4327984579C2776217527 @default.
• W4327984579 hasConceptScore W4327984579C2776946954 @default.
• W4327984579 hasConceptScore W4327984579C2776953665 @default.
• W4327984579 hasConceptScore W4327984579C2777050526 @default.
• W4327984579 hasConceptScore W4327984579C2778690821 @default.
• W4327984579 hasConceptScore W4327984579C71924100 @default.
• W4327984579 hasConceptScore W4327984579C8891405 @default.
• W4327984579 hasConceptScore W4327984579C98274493 @default.
• W4327984579 hasFunder F4320322113 @default.
• W4327984579 hasIssue "6" @default.
• W4327984579 hasLocation W43279845791 @default.
• W4327984579 hasLocation W43279845792 @default.
• W4327984579 hasLocation W43279845793 @default.
• W4327984579 hasOpenAccess W4327984579 @default.
• W4327984579 hasPrimaryLocation W43279845791 @default.
• W4327984579 hasRelatedWork W1585733337 @default.
• W4327984579 hasRelatedWork W1975985310 @default.
• W4327984579 hasRelatedWork W2029245561 @default.
• W4327984579 hasRelatedWork W2092359331 @default.
• W4327984579 hasRelatedWork W2099512139 @default.
• W4327984579 hasRelatedWork W2105666819 @default.
• W4327984579 hasRelatedWork W2159281402 @default.

• next