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- W4328000854 abstract "Summary: Screening of all the cases of Candida meningitis accessible to the authors from the literature of the last 40 years has shown that amphotericin B and 5-fluorocytosin have lowered the mortality rate by 7 1/2 times compared with the period before 1958. The combination of amphotericin B and 5-fluorocytosin is significantly more effective than amphotericin B alone and seems to bring the mortality rate down to almost nil. The number of cures without residual mental handicap has however only doubled. Of the survivors, almost one-third still suffer long-term damage as a result of this disease, a proportion similar to that recorded in the pre-antimycotic era. Zusammenfassung: Die Sichtung sämtlicher den Verfassern zugänglichen Candida-Meningitiden der Literatur der letzten 40 Jahre hat gezeigt, daß Amphotericin B und 5-Fluorocytosin die Sterblichkeit, verglichen mit der Zeit vor 1958, um das 7 1/2-fache gesenkt haben. Die Kombination von Amphotericin B und 5-Fluoro-cytosin ist bedeutend wirksamer als die Applikation von Amphotericin B allein und scheint die Letalität sogar gegen Null zu verschieben. Die Heilungen ohne Defekt sind aber nur um das Doppelte angestiegen. Von den überlebenden trägt auch weiterhin fast ein Drittel Spätschäden davon, ähnlich wie in der vor-antimycotischen Aera." @default.
- W4328000854 created "2023-03-22" @default.
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- W4328000854 date "2009-04-24" @default.
- W4328000854 modified "2023-09-30" @default.
- W4328000854 title "Candida Meningitis/Course, Prognosis and Mortality before and after Introduction of the New Antimycotics. Die Candida Meningitis: Verlauf, Prognose und Letalität vor und nach Einführung der neuen Antimycotica" @default.
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- W4328000854 doi "https://doi.org/10.1111/j.1439-0507.1983.tb03175.x" @default.
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