Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328000949> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4328000949 endingPage "35" @default.
- W4328000949 startingPage "29" @default.
- W4328000949 abstract "Summary The concerted activation of leukocytes and vessels shapes multiple physiological and pathological responses. A large number of these processes shares a common signal transduction platform involving the activation of plasma membrane bound G protein-coupled receptors (GPCRs). This event is usually amplified by the production of different intra-cellular second messenger molecules. Among these mediators, the phosphorylated lipid phosphatidylinositol (3,4,5)-trisphosphate (PIP3) produced by phosphoinositide 3-kinase γ (PI3Kγ) has recently emerged as a crucial signal in both vascular and white blood cells. The generation of mice lacking PI3Kγ showed that the GPCR/PI3Kγ/PIP3 signaling pathway controls diverse immune modulatory and vascular functions like respiratory burst, cell recruitment, mast cell reactivity, platelet aggregation, endothelial activation as well as smooth muscle contractility. The relative specificity of these events suggests that blocking PI3Kγ function might turn out beneficial for diseases like inflammation, allergy, thrombosis, and major cardiovascular disorders like hypertension, thus offering a wide range of therapeutic opportunities." @default.
- W4328000949 created "2023-03-22" @default.
- W4328000949 creator A5027985482 @default.
- W4328000949 creator A5035165920 @default.
- W4328000949 creator A5040148157 @default.
- W4328000949 creator A5048164631 @default.
- W4328000949 creator A5059938229 @default.
- W4328000949 creator A5085452501 @default.
- W4328000949 date "2006-01-01" @default.
- W4328000949 modified "2023-10-04" @default.
- W4328000949 title "Signaling through PI3Kγ: a common platform for leukocyte, platelet and cardiovascular stress sensing" @default.
- W4328000949 doi "https://doi.org/10.1160/th05-07-0476" @default.
- W4328000949 hasPublicationYear "2006" @default.
- W4328000949 type Work @default.
- W4328000949 citedByCount "36" @default.
- W4328000949 countsByYear W43280009492012 @default.
- W4328000949 countsByYear W43280009492013 @default.
- W4328000949 countsByYear W43280009492014 @default.
- W4328000949 countsByYear W43280009492015 @default.
- W4328000949 countsByYear W43280009492016 @default.
- W4328000949 countsByYear W43280009492017 @default.
- W4328000949 countsByYear W43280009492019 @default.
- W4328000949 countsByYear W43280009492020 @default.
- W4328000949 countsByYear W43280009492021 @default.
- W4328000949 crossrefType "journal-article" @default.
- W4328000949 hasAuthorship W4328000949A5027985482 @default.
- W4328000949 hasAuthorship W4328000949A5035165920 @default.
- W4328000949 hasAuthorship W4328000949A5040148157 @default.
- W4328000949 hasAuthorship W4328000949A5048164631 @default.
- W4328000949 hasAuthorship W4328000949A5059938229 @default.
- W4328000949 hasAuthorship W4328000949A5085452501 @default.
- W4328000949 hasConcept C126322002 @default.
- W4328000949 hasConcept C135285700 @default.
- W4328000949 hasConcept C163235415 @default.
- W4328000949 hasConcept C170493617 @default.
- W4328000949 hasConcept C180899940 @default.
- W4328000949 hasConcept C203014093 @default.
- W4328000949 hasConcept C2776914184 @default.
- W4328000949 hasConcept C2780610907 @default.
- W4328000949 hasConcept C2781322055 @default.
- W4328000949 hasConcept C3018697912 @default.
- W4328000949 hasConcept C62478195 @default.
- W4328000949 hasConcept C71924100 @default.
- W4328000949 hasConcept C86554907 @default.
- W4328000949 hasConcept C86803240 @default.
- W4328000949 hasConcept C8891405 @default.
- W4328000949 hasConcept C89560881 @default.
- W4328000949 hasConcept C95444343 @default.
- W4328000949 hasConceptScore W4328000949C126322002 @default.
- W4328000949 hasConceptScore W4328000949C135285700 @default.
- W4328000949 hasConceptScore W4328000949C163235415 @default.
- W4328000949 hasConceptScore W4328000949C170493617 @default.
- W4328000949 hasConceptScore W4328000949C180899940 @default.
- W4328000949 hasConceptScore W4328000949C203014093 @default.
- W4328000949 hasConceptScore W4328000949C2776914184 @default.
- W4328000949 hasConceptScore W4328000949C2780610907 @default.
- W4328000949 hasConceptScore W4328000949C2781322055 @default.
- W4328000949 hasConceptScore W4328000949C3018697912 @default.
- W4328000949 hasConceptScore W4328000949C62478195 @default.
- W4328000949 hasConceptScore W4328000949C71924100 @default.
- W4328000949 hasConceptScore W4328000949C86554907 @default.
- W4328000949 hasConceptScore W4328000949C86803240 @default.
- W4328000949 hasConceptScore W4328000949C8891405 @default.
- W4328000949 hasConceptScore W4328000949C89560881 @default.
- W4328000949 hasConceptScore W4328000949C95444343 @default.
- W4328000949 hasIssue "01" @default.
- W4328000949 hasLocation W43280009491 @default.
- W4328000949 hasOpenAccess W4328000949 @default.
- W4328000949 hasPrimaryLocation W43280009491 @default.
- W4328000949 hasRelatedWork W1603439931 @default.
- W4328000949 hasRelatedWork W1973540164 @default.
- W4328000949 hasRelatedWork W2012134847 @default.
- W4328000949 hasRelatedWork W2012549345 @default.
- W4328000949 hasRelatedWork W2050481377 @default.
- W4328000949 hasRelatedWork W2093676869 @default.
- W4328000949 hasRelatedWork W2094336459 @default.
- W4328000949 hasRelatedWork W2118560029 @default.
- W4328000949 hasRelatedWork W3081180842 @default.
- W4328000949 hasRelatedWork W4328000949 @default.
- W4328000949 hasVolume "95" @default.
- W4328000949 isParatext "false" @default.
- W4328000949 isRetracted "false" @default.
- W4328000949 workType "article" @default.