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• W4328001051 abstract "The effects of two suspected endocrine-disrupting chemicals, the xeno-androgens triphenyltin (TPT) and tributyltin (TBT), were investigated in a new whole-sediment biotest with the freshwater mudsnail Potamopyrgus antipodarum (Gastropoda, Prosobranchia). Artificial sediments were spiked with seven concentrations, ranging from 10 to 500 μg nominal TPT-Sn/kg dry weight and TBT-Sn/kg dry weight, respectively. We analyzed the responses of the test species after two, four, and eight weeks exposure. For both compounds, P. antipodarum exhibited a sharp decline in the number of embryos sheltered in its brood pouch in a time- and concentration-dependent manner in comparison to the control sediment. The number of new, still unshelled embryos turned out to be the most sensitive parameter. The lowest-observed-effect concentration (LOEC) was equivalent to the lowest administered concentration (10 μg/kg of each test compound) for most parameters and thus no no-observed-effect concentration (NOEC) could be established. The calculation of effect concentrations (EC10) resulted in even lower values for both substances (EC10 after eight weeks for unshelled embryos: 0.03 μg TPT-Sn/kg, EC10 after four weeks for unshelled embryos: 0.98 μg TBT-Sn/kg). Our results indicate that P. antipodarum is highly sensitive to both endocrine disruptors TPT and TBT at environmentally relevant concentrations." @default.
• W4328001051 created "2023-03-22" @default.
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• W4328001051 date "2003-01-01" @default.
• W4328001051 modified "2023-10-17" @default.
• W4328001051 title "Toxicity of triphenyltin and tributyltin to the freshwater mud snail<i>Potamopyrgus antipodarum</i>in a new sediment biotest" @default.
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• W4328001051 doi "https://doi.org/10.1002/etc.5620220119" @default.
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