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- W4328012711 abstract "BackgroundThe eye shares striking structural, developmental, and genetic pathways with the kidney, suggesting that kidney disease and ocular disease may be closely linked.ObjectivesTo assess retinal and choroidal thickness in patients with chronic kidney disease (CKD) using spectral-domain optical coherence tomography.Patients and methodsThis was a cross-sectional study conducted at Menoufia University Hospital Ophthalmology Department on 144 eyes of 72 CKD patients, who were divided into three groups according to the stage of CKD as follows: group 1: CKD stage 1–2, estimated glomerular filtration rate (eGFR) more than 60 ml/min/1.73m2, group 2: CKD stage 3, eGFR 30–59 ml/min/1.73m2, and group 3: CKD stage 4–5, eGFR less than 29 ml/min/1.73m2. Each subject underwent a full ophthalmologic examination followed by optical coherence tomography assessment of retinal, retinal nerve fiber layer, and choroidal thickness. The procedure was achieved with pupillary dilatation.ResultsRetinal thickness and choroidal thickness were reduced in group 2 and group 3 compared with group 1 (for retinal thickness P = 0.015 for group 3 vs. group 1 and P = 0.022 for group 2 vs. group 1; for choroidal thickness P < 0.001 for group 2 and group 3 vs. group 1). This reduction was more in group 3 than in group 2.ConclusionThis study revealed that chorioretinal thinning in CKD is associated with a lower eGFR, a higher serum C-reactive protein, and greater proteinuria. Larger studies, in more targeted groups of patients, are now needed to clarify whether these eye changes reflect the natural history of CKD. Similarly, associations with arterial stiffness, inflammation, and endothelial dysfunction warrant further examination." @default.
- W4328012711 created "2023-03-22" @default.
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- W4328012711 date "2022-01-01" @default.
- W4328012711 modified "2023-10-01" @default.
- W4328012711 title "Association of chorioretinal thickness with chronic kidney disease" @default.
- W4328012711 cites W3004851859 @default.
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- W4328012711 doi "https://doi.org/10.4103/mmj.mmj_199_22" @default.
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