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• W4328012794 abstract "ObjectivesTo assess the platelet (PLT) indices, such as mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW), in pulmonary embolism (PE) prediction.BackgroundPE is the third most frequent cardiovascular disease worldwide. The changes in PLT indices (MPV, PDW, and PCT) are gold standard markers for the pathogenesis in different cardiovascular diseases.Patients and methodsA total of 100 patients with venous thromboembolism and 50 controls were recruited. Overall, 46 patients presented with first episode of deep venous thrombosis (DVT) without PE (group I) and 54 patients with PE (group II).ResultsMPV was significantly higher in patients with PE (10.72 ± 2.05 fl) than patients with DVT (9.25 ± 1.31 fl) (P = 0.02). Similarly, PDW was significantly higher in patients with PE (24.78 ± 6.76 fl) than patients with DVT (22.39 ± 4.33 fl), with P value of 0.04. The cutoff values of MPV and PDW for prediction of PE at presentation were 10 and 17.5 fl, respectively, with sensitivities of 77 and 83%, respectively, and specificities of 87 and 80%, respectively. PCT was significantly higher in the PE (0.25 ± 0.09 ng/ml) group and DVT (0.26 ± 0.07 ng/ml) group compared with the control (0.22 ± 0.04 ng/ml) group. PLT count was significantly lower in the PE group (229.39 ± 67.98 × 103/μl) than DVT (249.85 ± 54.7 × 103/μl) and control (279.13 ± 61.83 × 103/μl) groups. White blood cell were significantly higher in patients with PE (9.36 ± 3.67 × 109/l) than DVT (8.01 ± 2.53 × 109/l) and control (8 ± 2.37 × 109/l) groups. The highest values of MPV, PDW, right ventricular dimensions, pulmonary pressure, and cardiac troponin I level were significantly correlated to the severity of PE. MPV and PDW were directly related to thrombus size in Doppler ultrasonography finding in patients with DVT and to the level of obstruction of pulmonary vessels in computed tomography pulmonary angiogram for patients with PE.ConclusionThe current study suggested that serial measurements of MPV, PDW, and PLT count are reliable markers for predicting the occurrence of acute PE in patients with first episode of acute proximal DVT." @default.
• W4328012794 created "2023-03-22" @default.
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• W4328012794 date "2022-01-01" @default.
• W4328012794 modified "2023-09-30" @default.
• W4328012794 title "Value of platelet indices in prediction of pulmonary embolism" @default.
• W4328012794 cites W3160038172 @default.
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• W4328012794 doi "https://doi.org/10.4103/mmj.mmj_247_22" @default.
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