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- W4328013147 abstract "ObjectiveTo explore the possible relation between serum growth differentiation factor 15 (GDF-15) level and carotid intima-media thickness (CIMT) test in patients with rheumatoid arthritis (RA).BackgroundGDF-15 plays an important role in cell growth and apoptosis regulation. GDF-15 is connected to RA, suggesting that it is a proinflammatory cytokine and etiologic factor for both RA and cardiovascular disease.Patients and methodsThis was a case–control study conducted on 50 patients with RA who were compared with 25 sex-matched and age-matched control group. GDF-15 levels were measured in blood samples from patients and controls by enzyme-linked immunosorbent assay, and CIMT was measured using Doppler ultrasonography. Medical data were collected regarding the patients' clinical manifestations, comorbidities, and treatments. The disease activity score-28 was used to evaluate the disease activity of RA.ResultsMedian GDF-15 level showed a significant increase in patients with RA (246.3 pg/ml) compared with controls (130.6 pg/ml), with P value less than 0.001. Right CIMT and left CIMT were significantly higher in patients with RA (P = 0.016 and 0.006, respectively). GDF-15 level showed a significant positive correlation with CIMT (P < 0.05). Age, disease duration, total cholesterol, and GDF-15 were independent risk factors for an elevated CIMT, with an odds ratio of 5.376, 4.659, 4.472, 1.905, 8.816, and 5.366, respectively.ConclusionPatients with RA had considerably greater levels of GDF-15 and CIMT than controls. Furthermore, in RA, GDF-15 was linked to an increased risk of subclinical atherosclerosis in those patients." @default.
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- W4328013147 date "2022-01-01" @default.
- W4328013147 modified "2023-09-26" @default.
- W4328013147 title "Growth differentiation factor 15: a possible link between rheumatoid arthritis and atherosclerosis" @default.
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- W4328013147 doi "https://doi.org/10.4103/mmj.mmj_231_22" @default.
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