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- W4328013151 abstract "Background: CLIC1, a metamorphic ion channel, can exist as a soluble monomer and on sensing oxidative stress can dimerize and further oligomerize to form a functional ion channel on the membrane. CLIC1 overexpression is associated with poor prognosis and metastasis in GBM, colorectal cancer, HNSCC, and HCC. Ion channels are promising therapeutic targets, but most of them have a normal physiological function and targeting them have adverse side effects. Since CLIC1 is known to preferentially localize on the membrane of cancer cells, taking advantage of the existing CLIC1 structure to repurpose FDA-approved drugs reduces the risk of adverse side effects." @default.
- W4328013151 created "2023-03-22" @default.
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- W4328013151 date "2022-08-01" @default.
- W4328013151 modified "2023-10-07" @default.
- W4328013151 title "Identification and Characterization of FDA-Approved Drugs as Novel Binders of CLIC1" @default.
- W4328013151 doi "https://doi.org/10.1055/s-0042-1755516" @default.
- W4328013151 hasPublicationYear "2022" @default.
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