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- W4328013598 abstract "ObjectivesTo assess the diagnostic value of the urinary intestinal fatty acid-binding protein (iFABP) in neonatal necrotizing enterocolitis (NEC) in the early stage of the disease.BackgroundNEC is a severe acute gastrointestinal disease affecting preterm newborns. iFABP has been associated with injury to the intestinal mucosa common to NEC.Patients and methodsThis cross-sectional study included 40 preterm neonates divided into two groups: group I included 20 preterm neonates with suspected NEC according to Modified Bell Staging Criteria for NEC and group II included 20 preterm neonates with non-NEC. All the included participants underwent full history taking, full examination, routine laboratory investigations, and assessment of urinary iFABP.ResultsThe mean urinary iFABP level was 17.26 ± 3.69 ng/dl in group I and 8.39 ± 2.49 ng/ml in group II. This difference was significantly higher in the suspected NEC group (P = 0.001). The iFABP level at a cutoff more than 9.25 ng/ml had significant power of discrimination of NEC cases at an early stage (P = 0.001) with a sensitivity of 96.0% and specificity of 71.0%. Linear regression revealed that the sampling time was a significant measure for prediction of iFABP (P = 0.001).ConclusionThere was an association between elevated iFABP levels in urine and NEC, suggesting that iFABP may be useful as a diagnostic biomarker for earlier identification of NEC." @default.
- W4328013598 created "2023-03-22" @default.
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- W4328013598 date "2022-01-01" @default.
- W4328013598 modified "2023-10-14" @default.
- W4328013598 title "Urine-based detection of intestinal mucosal cell damage in neonates with suspected necrotizing enterocolitis" @default.
- W4328013598 cites W1988659465 @default.
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- W4328013598 doi "https://doi.org/10.4103/mmj.mmj_271_22" @default.
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