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- W4328013632 abstract "ObjectiveTo determine potential diagnostic and prognostic values of programmed death receptor-1 (PD-1) expression in neonatal sepsis.BackgroundIn neonatal ICUs across the world, sepsis is a frequent disease associated with high rates of death and morbidity. In sepsis, chronic immunosuppression following a fast proinflammatory response results in high rates of morbidity and death. PD-1 (CD279) is an immunoglobulin superfamily cell surface receptor that inhibits proinflammatory activity.Patients and methodsThis prospective observational study was carried out on 102 newborns. They were divided into two groups: group I (cases group) (n = 52) included newborns with suspected or proven sepsis, while group II (control group) (n = 50) included age and sex-matched newborns, who did not develop neonatal sepsis. Group I was further subdivided into group Ia (n = 42), which included the surviving newborns and group Ib (n = 10), which included the nonsurviving newborns.ResultsMean fluorescence intensity for PD-1 was significantly higher in cases than in controls (P < 0.05). Mean fluorescence intensity with a cutoff point more than 1610.1 has the highest sensitivity (71.15%) and specificity (60%) for the prediction of sepsis, negative predictive value (66.7%), and positive predictive value (64.9%).PD-1 percentage on lymphocytes has the highest sensitivity (80%) and specificity (66.67%) in the prediction of mortality with a cutoff point more than 3.09.ConclusionThe expression of PD-1 on lymphocytes may serve as a diagnostic marker for newborn sepsis and a mortality predictor." @default.
- W4328013632 created "2023-03-22" @default.
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- W4328013632 date "2022-01-01" @default.
- W4328013632 modified "2023-10-14" @default.
- W4328013632 title "Programmed death receptor-1 expression in neonatal sepsis as a diagnostic and prognostic marker" @default.
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- W4328013632 doi "https://doi.org/10.4103/mmj.mmj_328_22" @default.
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