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- W4328013660 abstract "BackgroundVentricular septal defect (VSD) leads left-to-right shunt with volume-overloaded left atrium (LA) and left ventricle. LA enlargement has been shown to be a reliable predictor of adverse cardiovascular outcomes.ObjectivesTo assess LA function in VSD patients by two-dimensional speckle tracking echocardiography.Patients and methodsThis retrospective study included 30 VSD patients aged less than 6 years (group I) and 30 age-matched and sex-matched normal controls (group II). All included individuals underwent detailed history taking, thorough clinical examination, and 12-lead ECG. With transthoracic echocardiography, we measured the LA volume. Assessment of LA reservoir, conduit, and pump functions was done using two-dimensional speckle tracking imaging.ResultsThere was a statistically significant greater (P = 0.002), LA volume, and a statistically highly significant lower (P < 0.001). LA global contractile strain among group I than group II. However, there were nonsignificantly higher and lower strain values for reservoir and conduit functions, respectively (P = 0.383 and 0.842, respectively) between both groups. There was a correlation between age and LA phasic functions and there was a statistically highly significant positive correlation between age and both peak atrial global reservoir strain and LA volume (P < 0.001) with a statistically significant negative correlation with LA contractile strain in group I compared with group II.ConclusionHemodymically, VSD leads to LA volume overload that affects the LA mechanical function, especially reservoir and contractility. This effect increases with age progression if left uncorrected." @default.
- W4328013660 created "2023-03-22" @default.
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- W4328013660 date "2022-01-01" @default.
- W4328013660 modified "2023-10-01" @default.
- W4328013660 title "Assessment of left atrial phasic functions in patients with ventricular septal defect induced volume overload" @default.
- W4328013660 doi "https://doi.org/10.4103/mmj.mmj_251_22" @default.
- W4328013660 hasPublicationYear "2022" @default.
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