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- W4328014563 abstract "Liver cirrhosis is 10th most common cause of death in the western world. It is associated with increased intestinal permeability as well as alterations of the gut microbiome. However, it is not understood how intestinal permeability and the microbiome are interrelated in cirrhosis. Therefore, we aim to investigate whether gut permeability biomarkers can predict mortality, their relation to microbiome composition and link these changes to a clinical outcome. Stool and serum samples from 78 cirrhotic patients were obtained and Intestinal permeability assessed by zonulin and diamine oxidase (DAO). Survival was assessed after 24 and 36 months. Kaplan-Mayer survival analysis and group comparisons were performed. Gut microbiome 16s rRNA sequencing data were analyzed by diversity metrics, ANCOM and LEfSe. At baseline neither zonulin nor DAO could predict mortality, but assessing the development over six months, patients whose zonulin levels worsened or did not change (n=45) had a higher mortality than those whose zonulin levels improved (n=33) (p=0.048). Microbiome composition (alpha- and beta diversity) did not differ between the patient groups. When analysing the microbiome with diversity metrics, the genus Phascolarctobacterium was more abundant in patients with improved intestinal permeability. Higher abundance of Phascolarctobacterium was associated with better hepatic function, whereas patients with a low abundance had a higher mortality after 24 months (p=0.004) as well as after 36 months (p= 0.007). Worsening of zonulin levels over six months predicted mortality in patients with liver cirrhosis, indicating that serial assessments of this biomarker improve its predictive power. Phascolarctobacterium was more abundant in patients with improved intestinal permeability and in patients with better hepatic function. Low abundance of Phascolarctobacterium could predict survival in cirrhotic patients and might be interesting as probiotic." @default.
- W4328014563 created "2023-03-22" @default.
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- W4328014563 date "2022-08-01" @default.
- W4328014563 modified "2023-09-26" @default.
- W4328014563 title "Differences in microbiome composition in cirrhotic patients with increased intestinal permeability" @default.
- W4328014563 doi "https://doi.org/10.1055/s-0042-1755772" @default.
- W4328014563 hasPublicationYear "2022" @default.
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