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- W4328014570 abstract "Background Due to recent GWAS studies we currently identified more than 200 risk loci that provide risk for the development of IBD, while the pathomechanism behind most of these variants is still unresolved. We could recently show that an impaired activity of the antioxidative enzyme Glutathione peroxidase 4 (Gpx4) in intestinal epithelial cells (IECs), a feature of human CD, leads to an inflammatory response in the context of dietary polyunsaturated fatty acid (PUFA) excess. Reduced Gpx4 activity in cells is known to trigger a form of programmed cell death termed ferroptosis as well as the degradation of the iron storage protein ferritin via a process termed ferritinophagy belonging to the autophagic maschinery. Here we show that autophagy is a hallmark in Gpx4 restricted cytokine production in IECs." @default.
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- W4328014570 date "2022-08-01" @default.
- W4328014570 modified "2023-09-25" @default.
- W4328014570 title "A role of autophagy in diet-induced metabolic enteritis" @default.
- W4328014570 doi "https://doi.org/10.1055/s-0042-1755724" @default.
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