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- W4328014596 abstract "Background Lynch syndrome (LS) is the most common familial cancer predisposition syndrome. Tumorigenesis is associated with an underlying defect in the cellular mismatch repair system and an an early onset (<45 years). Therefore, chemopreventive measures are needed. The Nuclear factor-erythroid 2-related factor (Nrf2) is a key regulator in the antioxidant response pathway and is often overexpressed in cancers to promote carcinogenesis. The role of Nrf2 in LS is not known." @default.
- W4328014596 created "2023-03-22" @default.
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- W4328014596 date "2022-08-01" @default.
- W4328014596 modified "2023-09-26" @default.
- W4328014596 title "Loss of Nrf2 decreases tumorigenesis in a mouse model of Lynch Syndrome and is associated with an increase in bacterial diversity" @default.
- W4328014596 doi "https://doi.org/10.1055/s-0042-1755760" @default.
- W4328014596 hasPublicationYear "2022" @default.
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