FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328023040> ?p ?o ?g. }

• W4328023040 endingPage "4113" @default.
• W4328023040 startingPage "4102" @default.
• W4328023040 abstract "Orthogonal therapy that combines CRISPR-based gene editing and prodrug-based chemotherapy is a promising approach to combat multidrug-resistant cancer. However, its potency to precisely regulate different therapeutic modalities in vivo is limited due to the lack of an integrated platform with high spatiotemporal resolution. Taking advantage of CRISPR technology, a Pt(iv)-based prodrug and orthogonal emissive upconversion nanoparticles (UCNPs), we herein rationally designed the first logic-gated CRISPR-Cas13d-based nanoprodrug for orthogonal photomodulation of gene editing and prodrug release for enhanced cancer therapy. The nanoprodrug (URL) was constructed by encapsulating a green light-activatable Pt(iv) prodrug and UV light-activatable Cas13d gene editing tool into UCNPs. We demonstrated that URL maintained excellent orthogonal emission behaviors under 808 and 980 nm excitations, allowing wavelength-selective photoactivation of Cas13d and the prodrug for downregulation of the resistance-related gene and induction of chemo-photodynamic therapy, respectively. Moreover, the photomodulation superiority of URL for overcoming drug resistance was highlighted by integrating it with a Boolean logic gate for programmable modulation of multiple cell behaviors. Importantly, in vivo studies demonstrated that URL can promote Pt(iv) prodrug activation and ROS generation and massively induce on-target drug accumulation by Cas13d-mediated drug resistance attenuation, delivering an ultimate chemo-photodynamic therapeutic performance in efficiently eradicating primary tumors and preventing further liver metastasis. Collectively, our results suggest that URL expands the Cas13d-based genome editing toolbox into prodrug nanomedicine and accelerates the discovery of new orthogonal therapeutic approaches." @default.
• W4328023040 created "2023-03-22" @default.
• W4328023040 creator A5032122445 @default.
• W4328023040 creator A5032331950 @default.
• W4328023040 creator A5059131186 @default.
• W4328023040 creator A5064455769 @default.
• W4328023040 creator A5068541553 @default.
• W4328023040 creator A5068717877 @default.
• W4328023040 creator A5069045530 @default.
• W4328023040 creator A5070556941 @default.
• W4328023040 creator A5076410530 @default.
• W4328023040 creator A5081489339 @default.
• W4328023040 date "2023-01-01" @default.
• W4328023040 modified "2023-10-14" @default.
• W4328023040 title "An orthogonally activatable CRISPR-Cas13d nanoprodrug to reverse chemoresistance for enhanced chemo-photodynamic therapy" @default.
• W4328023040 cites W2031407900 @default.
• W4328023040 cites W2120635383 @default.
• W4328023040 cites W2236761186 @default.
• W4328023040 cites W2520429885 @default.
• W4328023040 cites W2587161721 @default.
• W4328023040 cites W2606001457 @default.
• W4328023040 cites W2780750565 @default.
• W4328023040 cites W2785049746 @default.
• W4328023040 cites W2793349369 @default.
• W4328023040 cites W2801603436 @default.
• W4328023040 cites W2805980987 @default.
• W4328023040 cites W2900711064 @default.
• W4328023040 cites W2928073984 @default.
• W4328023040 cites W2937805576 @default.
• W4328023040 cites W2975113920 @default.
• W4328023040 cites W2984886661 @default.
• W4328023040 cites W2988773550 @default.
• W4328023040 cites W3002084570 @default.
• W4328023040 cites W3011049299 @default.
• W4328023040 cites W3011119456 @default.
• W4328023040 cites W3013235937 @default.
• W4328023040 cites W3015042299 @default.
• W4328023040 cites W3022483367 @default.
• W4328023040 cites W3023671064 @default.
• W4328023040 cites W3036227837 @default.
• W4328023040 cites W3036520293 @default.
• W4328023040 cites W3040880602 @default.
• W4328023040 cites W3043934334 @default.
• W4328023040 cites W3088884485 @default.
• W4328023040 cites W3093176404 @default.
• W4328023040 cites W3094040824 @default.
• W4328023040 cites W3109174541 @default.
• W4328023040 cites W3118878140 @default.
• W4328023040 cites W3126719866 @default.
• W4328023040 cites W3149231384 @default.
• W4328023040 cites W3194223146 @default.
• W4328023040 cites W4200380877 @default.
• W4328023040 cites W4220754660 @default.
• W4328023040 cites W4220795930 @default.
• W4328023040 cites W4220884757 @default.
• W4328023040 cites W4224260683 @default.
• W4328023040 cites W4281768840 @default.
• W4328023040 cites W4283009344 @default.
• W4328023040 cites W4308773145 @default.
• W4328023040 doi "https://doi.org/10.1039/d3sc00020f" @default.
• W4328023040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37063792" @default.
• W4328023040 hasPublicationYear "2023" @default.
• W4328023040 type Work @default.
• W4328023040 citedByCount "0" @default.
• W4328023040 crossrefType "journal-article" @default.
• W4328023040 hasAuthorship W4328023040A5032122445 @default.
• W4328023040 hasAuthorship W4328023040A5032331950 @default.
• W4328023040 hasAuthorship W4328023040A5059131186 @default.
• W4328023040 hasAuthorship W4328023040A5064455769 @default.
• W4328023040 hasAuthorship W4328023040A5068541553 @default.
• W4328023040 hasAuthorship W4328023040A5068717877 @default.
• W4328023040 hasAuthorship W4328023040A5069045530 @default.
• W4328023040 hasAuthorship W4328023040A5070556941 @default.
• W4328023040 hasAuthorship W4328023040A5076410530 @default.
• W4328023040 hasAuthorship W4328023040A5081489339 @default.
• W4328023040 hasBestOaLocation W43280230401 @default.
• W4328023040 hasConcept C104317684 @default.
• W4328023040 hasConcept C108215921 @default.
• W4328023040 hasConcept C111599444 @default.
• W4328023040 hasConcept C144501496 @default.
• W4328023040 hasConcept C150903083 @default.
• W4328023040 hasConcept C171250308 @default.
• W4328023040 hasConcept C178790620 @default.
• W4328023040 hasConcept C185592680 @default.
• W4328023040 hasConcept C192562407 @default.
• W4328023040 hasConcept C207001950 @default.
• W4328023040 hasConcept C2781323092 @default.
• W4328023040 hasConcept C502942594 @default.
• W4328023040 hasConcept C55493867 @default.
• W4328023040 hasConcept C70721500 @default.
• W4328023040 hasConcept C86803240 @default.
• W4328023040 hasConcept C98108389 @default.
• W4328023040 hasConcept C98274493 @default.
• W4328023040 hasConceptScore W4328023040C104317684 @default.
• W4328023040 hasConceptScore W4328023040C108215921 @default.
• W4328023040 hasConceptScore W4328023040C111599444 @default.
• W4328023040 hasConceptScore W4328023040C144501496 @default.
• W4328023040 hasConceptScore W4328023040C150903083 @default.

• next