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- W4328048881 endingPage "411" @default.
- W4328048881 startingPage "400" @default.
- W4328048881 abstract "Abstract Tumour immunotherapy has achieved good therapeutic effects in clinical practice and has received increased attention. Cytotoxic T cells undoubtedly play an important role in tumour immunotherapy. As a revolutionary tumour immunotherapy approach, chimeric antigen receptor T‐cell (CAR‐T‐cell) therapy has made breakthroughs in the treatment of haematological cancers. However, T cells are easily exhausted in vivo, especially after they enter solid tumours. The exhaustion of T cells can lead to poor results of CAR‐T‐cell therapy in the treatment of solid tumours. Here, we review the reasons for T‐cell exhaustion and how T‐cell exhaustion develops. We also review and discuss ways to improve CAR‐T‐cell therapy effects by regulating T‐cell exhaustion." @default.
- W4328048881 created "2023-03-22" @default.
- W4328048881 creator A5036025717 @default.
- W4328048881 creator A5069351874 @default.
- W4328048881 creator A5071297926 @default.
- W4328048881 date "2023-03-20" @default.
- W4328048881 modified "2023-10-17" @default.
- W4328048881 title "T‐cell exhaustion in <scp>CAR‐T</scp>‐cell therapy and strategies to overcome it" @default.
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