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• W4328049094 abstract "Intra-amniotic inflammation (IAI), associated with either microbe (infection) or danger signals (sterile), plays a major role in the pathophysiology of preterm labor and delivery. Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2) [also known as Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1)], a mitochondrial protein involved in oxidative phosphorylation and cell survival, is capable of sensing tissue hypoxia and inflammatory signaling. The ability to maintain an appropriate energy balance at the cellular level while adapting to environmental stress is essential for the survival of an organism. Mitochondrial dysfunction has been observed in acute systemic inflammatory conditions, such as sepsis, and is proposed to be involved in sepsis-induced multi-organ failure. The purpose of this study was to determine the amniotic fluid concentrations of CHCHD2/MNRR1 in pregnant women, women at term in labor, and those in preterm labor (PTL) with and without IAI.This cross-sectional study comprised patients allocated to the following groups: (1) mid-trimester (n = 16); (2) term in labor (n = 37); (3) term not in labor (n = 22); (4) PTL without IAI who delivered at term (n = 25); (5) PTL without IAI who delivered preterm (n = 47); and (6) PTL with IAI who delivered preterm (n = 53). Diagnosis of IAI (amniotic fluid interleukin-6 concentration ≥2.6 ng/mL) included cases associated with microbial invasion of the amniotic cavity and those of sterile nature (absence of detectable bacteria, using culture and molecular microbiology techniques). Amniotic fluid and maternal plasma CHCHD2/MNRR1 concentrations were determined with a validated and sensitive immunoassay.(1) CHCHD2/MNRR1 was detectable in all amniotic fluid samples and women at term without labor had a higher amniotic fluid CHCHD2/MNRR1 concentration than those in the mid-trimester (p = 0.003); (2) the amniotic fluid concentration of CHCHD2/MNRR1 in women at term in labor was higher than that in women at term without labor (p = 0.01); (3) women with PTL and IAI had a higher amniotic fluid CHCHD2/MNRR1 concentration than those without IAI, either with preterm (p < 0.001) or term delivery (p = 0.01); (4) women with microbial-associated IAI had a higher amniotic fluid CHCHD2/MNRR1 concentration than those with sterile IAI (p < 0.001); (5) among women with PTL and IAI, the amniotic fluid concentration of CHCHD2/MNRR1 correlated with that of interleukin-6 (Spearman's Rho = 0.7; p < 0.001); and (6) no correlation was observed between amniotic fluid and maternal plasma CHCHD2/MNRR1 concentrations among women with PTL.CHCHD2/MNRR1 is a physiological constituent of human amniotic fluid in normal pregnancy, and the amniotic concentration of this mitochondrial protein increases during pregnancy, labor at term, and preterm labor with intra-amniotic infection. Hence, CHCHD2/MNRR1 may be released into the amniotic cavity by dysfunctional mitochondria during microbial-associated IAI." @default.
• W4328049094 created "2023-03-22" @default.
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• W4328049094 date "2023-03-20" @default.
• W4328049094 modified "2023-10-18" @default.
• W4328049094 title "Evidence for the participation of CHCHD2/MNRR1, a mitochondrial protein, in spontaneous labor at term and in preterm labor with intra-amniotic infection" @default.
• W4328049094 cites W1008189539 @default.
• W4328049094 cites W1541003209 @default.
• W4328049094 cites W1550067320 @default.
• W4328049094 cites W1563950821 @default.
• W4328049094 cites W1574971916 @default.
• W4328049094 cites W1585369682 @default.
• W4328049094 cites W1625374847 @default.
• W4328049094 cites W166801957 @default.
• W4328049094 cites W1963915233 @default.
• W4328049094 cites W1965332690 @default.
• W4328049094 cites W1965897259 @default.
• W4328049094 cites W1968508943 @default.
• W4328049094 cites W1968742530 @default.
• W4328049094 cites W1969717580 @default.
• W4328049094 cites W1970727168 @default.
• W4328049094 cites W1973025253 @default.
• W4328049094 cites W1973429877 @default.
• W4328049094 cites W1975755498 @default.
• W4328049094 cites W1976674406 @default.
• W4328049094 cites W1978668509 @default.
• W4328049094 cites W1979474833 @default.
• W4328049094 cites W1979995829 @default.
• W4328049094 cites W1983378030 @default.
• W4328049094 cites W1984221807 @default.
• W4328049094 cites W1985609571 @default.
• W4328049094 cites W1988813390 @default.
• W4328049094 cites W1989666280 @default.
• W4328049094 cites W1990845589 @default.
• W4328049094 cites W1992126014 @default.
• W4328049094 cites W1994261018 @default.
• W4328049094 cites W1994310214 @default.
• W4328049094 cites W1995785775 @default.
• W4328049094 cites W2002314341 @default.
• W4328049094 cites W2004264271 @default.
• W4328049094 cites W2010101647 @default.
• W4328049094 cites W2015626696 @default.
• W4328049094 cites W2017237000 @default.
• W4328049094 cites W2017975056 @default.
• W4328049094 cites W2024179737 @default.
• W4328049094 cites W2024364814 @default.
• W4328049094 cites W2024768515 @default.
• W4328049094 cites W2025193748 @default.
• W4328049094 cites W2026154773 @default.
• W4328049094 cites W2027035932 @default.
• W4328049094 cites W2032739461 @default.
• W4328049094 cites W2033784618 @default.
• W4328049094 cites W2036479825 @default.
• W4328049094 cites W2038019990 @default.
• W4328049094 cites W2039416528 @default.
• W4328049094 cites W2048507125 @default.
• W4328049094 cites W2049511993 @default.
• W4328049094 cites W2051572583 @default.
• W4328049094 cites W2051868855 @default.
• W4328049094 cites W2052833946 @default.
• W4328049094 cites W2055706903 @default.
• W4328049094 cites W2056228221 @default.
• W4328049094 cites W2057056307 @default.
• W4328049094 cites W2058029264 @default.
• W4328049094 cites W2058987514 @default.
• W4328049094 cites W2060204808 @default.
• W4328049094 cites W2062376206 @default.
• W4328049094 cites W2072605958 @default.
• W4328049094 cites W2076974773 @default.
• W4328049094 cites W2078052907 @default.
• W4328049094 cites W2082839336 @default.
• W4328049094 cites W2083729273 @default.
• W4328049094 cites W2087210742 @default.
• W4328049094 cites W2092077411 @default.
• W4328049094 cites W2092305714 @default.
• W4328049094 cites W2093277404 @default.
• W4328049094 cites W2093518043 @default.
• W4328049094 cites W2093782142 @default.
• W4328049094 cites W2094290207 @default.
• W4328049094 cites W2095508943 @default.
• W4328049094 cites W2105820857 @default.
• W4328049094 cites W2108813933 @default.
• W4328049094 cites W2109016292 @default.
• W4328049094 cites W2112027648 @default.
• W4328049094 cites W2118326567 @default.

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