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• W4328049102 abstract "The SARS-CoV-2 RNA vaccines are smartly designed to increase the synonymous codon usage by introducing multiple U-to-C mutations. This design would elevate the translation efficiency of vaccine RNAs. However, we found evidence to reason that the designed cytidines might be converted to uridines again by C-to-U RNA deamination in host cells. This C-to-U mechanism might be a main factor that affects the efficacy and safety of RNA vaccines." @default.
• W4328049102 created "2023-03-22" @default.
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• W4328049102 date "2023-03-21" @default.
• W4328049102 modified "2023-09-27" @default.
• W4328049102 title "The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing" @default.
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• W4328049102 doi "https://doi.org/10.1007/s13353-023-00756-w" @default.
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