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- W4328049137 abstract "Generalized pustular psoriasis (GPP) is often a life-threatening disease which, in contrast to psoriasis vulgaris, is associated with the formation of sterile pustules on the skin. Until recently, there was no approved treatment in Europe, so that drugs used for psoriasis vulgaris were also frequently used for GPP. However, new studies showed that, in GPP, mutation of the interleukin-36 receptor often leads to increased inflammation and corresponding disease activity. We report a case of GPP with complete remission after two doses of spesolimab, a new interleukin-36 receptor antibody.Die generalisierte pustulöse Psoriasis (GPP) ist eine inflammatorische Erkrankung, die prinzipiell lebensbedrohlich verlaufen kann. Im Gegensatz zur „klassischen“ Psoriasis (Psoriasis vulgaris) geht diese mit einer sterilen Pustelbildung auf erythematöser Haut einher. Bislang gab es in Europa keine suffiziente, zugelassene Therapieoption, sodass die für die Psoriasis vulgaris eingesetzten Medikamente auch bei der GPP Verwendung fanden. Neuere Studien belegen, dass bei der GPP oft eine Mutation des Interleukin-36-Rezeptor-Antagonisten (IL-36Ra) zu einer gesteigerten Inflammation und entsprechend zur Krankheitsaktivität führt. Wir berichten den Fall einer schweren GPP mit einer kompletten Remission nach 2‑maliger Gabe von Spesolimab, einem neuen Interleukin-36-Rezeptor-Antikörper." @default.
- W4328049137 created "2023-03-22" @default.
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- W4328049137 date "2023-03-21" @default.
- W4328049137 modified "2023-10-05" @default.
- W4328049137 title "Remission of recalcitrant generalized pustular psoriasis under interleukin-36 receptor inhibitor spesolimab" @default.
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- W4328049137 doi "https://doi.org/10.1007/s00105-023-05140-7" @default.
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