Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049194> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4328049194 endingPage "234" @default.
- W4328049194 startingPage "228" @default.
- W4328049194 abstract "Epithelium-derived antimicrobial peptides represent an evolutionarily ancient defense mechanism against pathogens. Regenerating islet-derived protein 3 γ (Reg3γ), the archetypal intestinal antimicrobial peptide, is critical for maintaining host-microbe interactions. Expression of Reg3γ is known to be regulated by the microbiota through two different pathways, although it remains unknown whether specific Reg3γ-inducing bacteria act via one or both of these pathways. In recent work, we identified Ruminococcus gnavus and Limosilactobacillus reuteri as commensal bacteria able to induce Reg3g expression. In this study, we show these bacteria require myeloid differentiation primary response protein 88 and group 3 innate lymphoid cells for induction of Reg3γ in mice. Interestingly, we find that R. gnavus and L. reuteri suppress Reg3γ in the absence of either myeloid differentiation primary response protein 88 or group 3 innate lymphoid cells. In addition, we demonstrate that colonization by these bacteria is not required for induction of Reg3γ, which occurs several days after transient exposure to the organisms. Taken together, our findings highlight the complex mechanisms underlying microbial regulation of Reg3γ." @default.
- W4328049194 created "2023-03-22" @default.
- W4328049194 creator A5011556881 @default.
- W4328049194 creator A5081527934 @default.
- W4328049194 date "2023-03-01" @default.
- W4328049194 modified "2023-09-25" @default.
- W4328049194 title "<i>Ruminococcus gnavus</i> and <i>Limosilactobacillus reuteri</i> Regulate Reg3γ Expression through Multiple Pathways" @default.
- W4328049194 doi "https://doi.org/10.4049/immunohorizons.2200096" @default.
- W4328049194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36943156" @default.
- W4328049194 hasPublicationYear "2023" @default.
- W4328049194 type Work @default.
- W4328049194 citedByCount "0" @default.
- W4328049194 crossrefType "journal-article" @default.
- W4328049194 hasAuthorship W4328049194A5011556881 @default.
- W4328049194 hasAuthorship W4328049194A5081527934 @default.
- W4328049194 hasBestOaLocation W43280491941 @default.
- W4328049194 hasConcept C136449434 @default.
- W4328049194 hasConcept C203014093 @default.
- W4328049194 hasConcept C2779282312 @default.
- W4328049194 hasConcept C2780027724 @default.
- W4328049194 hasConcept C47742525 @default.
- W4328049194 hasConcept C4937899 @default.
- W4328049194 hasConcept C523546767 @default.
- W4328049194 hasConcept C540938839 @default.
- W4328049194 hasConcept C54355233 @default.
- W4328049194 hasConcept C86803240 @default.
- W4328049194 hasConcept C8891405 @default.
- W4328049194 hasConcept C89423630 @default.
- W4328049194 hasConcept C95444343 @default.
- W4328049194 hasConceptScore W4328049194C136449434 @default.
- W4328049194 hasConceptScore W4328049194C203014093 @default.
- W4328049194 hasConceptScore W4328049194C2779282312 @default.
- W4328049194 hasConceptScore W4328049194C2780027724 @default.
- W4328049194 hasConceptScore W4328049194C47742525 @default.
- W4328049194 hasConceptScore W4328049194C4937899 @default.
- W4328049194 hasConceptScore W4328049194C523546767 @default.
- W4328049194 hasConceptScore W4328049194C540938839 @default.
- W4328049194 hasConceptScore W4328049194C54355233 @default.
- W4328049194 hasConceptScore W4328049194C86803240 @default.
- W4328049194 hasConceptScore W4328049194C8891405 @default.
- W4328049194 hasConceptScore W4328049194C89423630 @default.
- W4328049194 hasConceptScore W4328049194C95444343 @default.
- W4328049194 hasIssue "3" @default.
- W4328049194 hasLocation W43280491941 @default.
- W4328049194 hasLocation W43280491942 @default.
- W4328049194 hasOpenAccess W4328049194 @default.
- W4328049194 hasPrimaryLocation W43280491941 @default.
- W4328049194 hasRelatedWork W1661293674 @default.
- W4328049194 hasRelatedWork W1969711244 @default.
- W4328049194 hasRelatedWork W2267446069 @default.
- W4328049194 hasRelatedWork W2619415615 @default.
- W4328049194 hasRelatedWork W3017622558 @default.
- W4328049194 hasRelatedWork W4281729072 @default.
- W4328049194 hasRelatedWork W4312305738 @default.
- W4328049194 hasRelatedWork W4320494802 @default.
- W4328049194 hasRelatedWork W4320495555 @default.
- W4328049194 hasRelatedWork W2517848781 @default.
- W4328049194 hasVolume "7" @default.
- W4328049194 isParatext "false" @default.
- W4328049194 isRetracted "false" @default.
- W4328049194 workType "article" @default.