FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049252> ?p ?o ?g. }

• W4328049252 endingPage "1107" @default.
• W4328049252 startingPage "1100" @default.
• W4328049252 abstract "Abstract Aging is the root cause of several pathologies like neurological and cardiovascular diseases. Identifying compounds that improve health span and extend life span, called geroprotectors, could be crucial to preventing or at least delaying the onset of age-related diseases. In this regard, the nematode Caenorhabditis elegans (C. elegans) is emerging as an easy, efficient, low-cost model system to screen natural products and identify novel geroprotectors. Phenolic acids can be found in a wide range of natural products that are part of the human diet. Vanillic acid (VA) is a phenolic acid that has previously been attributed with antioxidant, anti-inflammatory, and neuroprotective features. To determine whether these beneficial health effects amount to an extension of health span and life span, in this work, we thoroughly explore the effect of VA on C. elegans stress resistance and life span. We found that VA increases thermotolerance (19.4%), reduces protein aggregation (between 30% and 40%), improves motility, and extends life span by almost 50%, an extent hardly ever achieved with a natural compound. The increased thermotolerance induced by VA is independent of the insulin/insulin-like growth factor-1 signaling pathway but requires heat shock factor-1 and is associated with increased heat shock protein-4 (HSP-4) and hsp-16.2 expression. These results provide new insight into understanding the therapeutical properties of VA and warrant further investigation of VA as a novel geroprotector." @default.
• W4328049252 created "2023-03-22" @default.
• W4328049252 creator A5035781049 @default.
• W4328049252 creator A5043902285 @default.
• W4328049252 creator A5080198858 @default.
• W4328049252 creator A5080626095 @default.
• W4328049252 date "2023-03-21" @default.
• W4328049252 modified "2023-10-08" @default.
• W4328049252 title "Vanillic Acid Improves Stress Resistance and Substantially Extends Life Span in <i>Caenorhabditis elegans</i>" @default.
• W4328049252 cites W1515599953 @default.
• W4328049252 cites W1535383539 @default.
• W4328049252 cites W1972199783 @default.
• W4328049252 cites W1975200549 @default.
• W4328049252 cites W1975595547 @default.
• W4328049252 cites W1992952078 @default.
• W4328049252 cites W1996372072 @default.
• W4328049252 cites W2001302985 @default.
• W4328049252 cites W2016918390 @default.
• W4328049252 cites W2032208441 @default.
• W4328049252 cites W2048746173 @default.
• W4328049252 cites W2050849379 @default.
• W4328049252 cites W2055730705 @default.
• W4328049252 cites W2100190412 @default.
• W4328049252 cites W2126525177 @default.
• W4328049252 cites W2128679613 @default.
• W4328049252 cites W2129704808 @default.
• W4328049252 cites W2136036483 @default.
• W4328049252 cites W2141444248 @default.
• W4328049252 cites W2195375432 @default.
• W4328049252 cites W2476101828 @default.
• W4328049252 cites W2515213755 @default.
• W4328049252 cites W2516639854 @default.
• W4328049252 cites W2537066862 @default.
• W4328049252 cites W2588627185 @default.
• W4328049252 cites W2590449460 @default.
• W4328049252 cites W2618158431 @default.
• W4328049252 cites W2766179553 @default.
• W4328049252 cites W2767304424 @default.
• W4328049252 cites W2769929186 @default.
• W4328049252 cites W2775829552 @default.
• W4328049252 cites W2794236080 @default.
• W4328049252 cites W2884798588 @default.
• W4328049252 cites W2899369171 @default.
• W4328049252 cites W2937495883 @default.
• W4328049252 cites W2951710934 @default.
• W4328049252 cites W2968272684 @default.
• W4328049252 cites W2970727613 @default.
• W4328049252 cites W2979833613 @default.
• W4328049252 cites W3087848978 @default.
• W4328049252 cites W3097521200 @default.
• W4328049252 cites W3122485118 @default.
• W4328049252 cites W3163579179 @default.
• W4328049252 cites W3171655772 @default.
• W4328049252 cites W4213039633 @default.
• W4328049252 cites W6697870 @default.
• W4328049252 doi "https://doi.org/10.1093/gerona/glad086" @default.
• W4328049252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36941756" @default.
• W4328049252 hasPublicationYear "2023" @default.
• W4328049252 type Work @default.
• W4328049252 citedByCount "2" @default.
• W4328049252 countsByYear W43280492522023 @default.
• W4328049252 crossrefType "journal-article" @default.
• W4328049252 hasAuthorship W4328049252A5035781049 @default.
• W4328049252 hasAuthorship W4328049252A5043902285 @default.
• W4328049252 hasAuthorship W4328049252A5080198858 @default.
• W4328049252 hasAuthorship W4328049252A5080626095 @default.
• W4328049252 hasConcept C104317684 @default.
• W4328049252 hasConcept C169760540 @default.
• W4328049252 hasConcept C25498285 @default.
• W4328049252 hasConcept C2778944004 @default.
• W4328049252 hasConcept C2988516024 @default.
• W4328049252 hasConcept C55493867 @default.
• W4328049252 hasConcept C78458016 @default.
• W4328049252 hasConcept C86803240 @default.
• W4328049252 hasConcept C95444343 @default.
• W4328049252 hasConceptScore W4328049252C104317684 @default.
• W4328049252 hasConceptScore W4328049252C169760540 @default.
• W4328049252 hasConceptScore W4328049252C25498285 @default.
• W4328049252 hasConceptScore W4328049252C2778944004 @default.
• W4328049252 hasConceptScore W4328049252C2988516024 @default.
• W4328049252 hasConceptScore W4328049252C55493867 @default.
• W4328049252 hasConceptScore W4328049252C78458016 @default.
• W4328049252 hasConceptScore W4328049252C86803240 @default.
• W4328049252 hasConceptScore W4328049252C95444343 @default.
• W4328049252 hasFunder F4320321739 @default.
• W4328049252 hasIssue "7" @default.
• W4328049252 hasLocation W43280492521 @default.
• W4328049252 hasLocation W43280492522 @default.
• W4328049252 hasOpenAccess W4328049252 @default.
• W4328049252 hasPrimaryLocation W43280492521 @default.
• W4328049252 hasRelatedWork W1616027798 @default.
• W4328049252 hasRelatedWork W1841816992 @default.
• W4328049252 hasRelatedWork W2029511489 @default.
• W4328049252 hasRelatedWork W2086107524 @default.
• W4328049252 hasRelatedWork W2141932099 @default.
• W4328049252 hasRelatedWork W2181461544 @default.
• W4328049252 hasRelatedWork W2317391614 @default.
• W4328049252 hasRelatedWork W3151667137 @default.

• next