FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049284> ?p ?o ?g. }

• W4328049284 endingPage "1939" @default.
• W4328049284 startingPage "1923" @default.
• W4328049284 abstract "Spinal cord injury (SCI) is a highly disabling condition in spinal surgery that leads to neuronal damage and secondary inflammation. Ferroptosis is a non-apoptotic type of cell death that has only recently been identified, which is marked primarily by iron-dependent and lipid-derived reactive oxygen species accumulation, and accompanied by morphological modifications such as mitochondrial atrophy and increase in membrane density. Dihydroorotate dehydrogenase (DHODH) is a powerful inhibitor of ferroptosis and has been demonstrated to inhibit cellular ferroptosis in tumor cells, but whether it can inhibit neuronal injury following spinal cord injury remains ambiguous.In this study, the effect of DHODH on neuronal ferroptosis was observed in vivo and in vitro using a rat spinal cord injury model and erastin-induced PC12 cells, respectively. A combination of molecular and histological approaches was performed to assess ferroptosis and explore the possible mechanisms in vivo and in vitro.First, we confirmed the existence of neuronal ferroptosis after spinal cord injury and that DHODH attenuates neuronal damage after spinal cord injury. Second, we showed molecular evidence that DHODH inhibits the activation of ferroptosis-related molecules and reduces lipid peroxide production and mitochondrial damage, thereby reducing neuronal ferroptosis. Further analysis suggests that P53/ALOX15 may be one of the mechanisms regulated by DHODH. Importantly, we determined that DHODH inhibits ALOX15 expression by inhibiting P53.Our findings reveal a novel function for DHODH in neuronal ferroptosis after spinal cord injury, suggesting a unique therapeutic target to alleviate the disease process of spinal cord injury." @default.
• W4328049284 created "2023-03-22" @default.
• W4328049284 creator A5012156586 @default.
• W4328049284 creator A5014800253 @default.
• W4328049284 creator A5015621758 @default.
• W4328049284 creator A5017135429 @default.
• W4328049284 creator A5018766553 @default.
• W4328049284 creator A5030865178 @default.
• W4328049284 creator A5032322896 @default.
• W4328049284 creator A5057477912 @default.
• W4328049284 creator A5064599467 @default.
• W4328049284 creator A5078147451 @default.
• W4328049284 creator A5086491465 @default.
• W4328049284 date "2023-03-21" @default.
• W4328049284 modified "2023-09-24" @default.
• W4328049284 title "Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the <scp>P53‐ALOX15</scp> signaling pathway" @default.
• W4328049284 cites W1842917036 @default.
• W4328049284 cites W1882823390 @default.
• W4328049284 cites W1975724680 @default.
• W4328049284 cites W1997183854 @default.
• W4328049284 cites W2004557153 @default.
• W4328049284 cites W2007794772 @default.
• W4328049284 cites W2021129711 @default.
• W4328049284 cites W2042899565 @default.
• W4328049284 cites W2047369546 @default.
• W4328049284 cites W2051097652 @default.
• W4328049284 cites W2067107606 @default.
• W4328049284 cites W2081053802 @default.
• W4328049284 cites W2090412310 @default.
• W4328049284 cites W2133959309 @default.
• W4328049284 cites W2166996710 @default.
• W4328049284 cites W2209442085 @default.
• W4328049284 cites W2225914140 @default.
• W4328049284 cites W2291832556 @default.
• W4328049284 cites W2343378530 @default.
• W4328049284 cites W2484283047 @default.
• W4328049284 cites W2508296626 @default.
• W4328049284 cites W2527907612 @default.
• W4328049284 cites W2529409645 @default.
• W4328049284 cites W2561420332 @default.
• W4328049284 cites W2599031841 @default.
• W4328049284 cites W2648604848 @default.
• W4328049284 cites W2739378577 @default.
• W4328049284 cites W2749918768 @default.
• W4328049284 cites W2752942423 @default.
• W4328049284 cites W2774959630 @default.
• W4328049284 cites W2780739174 @default.
• W4328049284 cites W2793033519 @default.
• W4328049284 cites W2802189972 @default.
• W4328049284 cites W2807183210 @default.
• W4328049284 cites W2899690662 @default.
• W4328049284 cites W2901562058 @default.
• W4328049284 cites W2906319220 @default.
• W4328049284 cites W2921265625 @default.
• W4328049284 cites W2924590879 @default.
• W4328049284 cites W2929402967 @default.
• W4328049284 cites W2988990722 @default.
• W4328049284 cites W3014895897 @default.
• W4328049284 cites W3031772441 @default.
• W4328049284 cites W3050108631 @default.
• W4328049284 cites W3099291212 @default.
• W4328049284 cites W3112312836 @default.
• W4328049284 cites W3128249412 @default.
• W4328049284 cites W3133988159 @default.
• W4328049284 cites W3154231578 @default.
• W4328049284 cites W3158500600 @default.
• W4328049284 cites W3159547083 @default.
• W4328049284 cites W3162306949 @default.
• W4328049284 cites W3163882711 @default.
• W4328049284 cites W3169236216 @default.
• W4328049284 cites W3169982265 @default.
• W4328049284 cites W4214639699 @default.
• W4328049284 cites W4224024971 @default.
• W4328049284 cites W4313682886 @default.
• W4328049284 cites W4316653380 @default.
• W4328049284 cites W4328049284 @default.
• W4328049284 cites W2003236021 @default.
• W4328049284 doi "https://doi.org/10.1111/cns.14150" @default.
• W4328049284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36942513" @default.
• W4328049284 hasPublicationYear "2023" @default.
• W4328049284 type Work @default.
• W4328049284 citedByCount "4" @default.
• W4328049284 countsByYear W43280492842023 @default.
• W4328049284 crossrefType "journal-article" @default.
• W4328049284 hasAuthorship W4328049284A5012156586 @default.
• W4328049284 hasAuthorship W4328049284A5014800253 @default.
• W4328049284 hasAuthorship W4328049284A5015621758 @default.
• W4328049284 hasAuthorship W4328049284A5017135429 @default.
• W4328049284 hasAuthorship W4328049284A5018766553 @default.
• W4328049284 hasAuthorship W4328049284A5030865178 @default.
• W4328049284 hasAuthorship W4328049284A5032322896 @default.
• W4328049284 hasAuthorship W4328049284A5057477912 @default.
• W4328049284 hasAuthorship W4328049284A5064599467 @default.
• W4328049284 hasAuthorship W4328049284A5078147451 @default.
• W4328049284 hasAuthorship W4328049284A5086491465 @default.
• W4328049284 hasBestOaLocation W43280492841 @default.
• W4328049284 hasConcept C150903083 @default.
• W4328049284 hasConcept C169760540 @default.

• next