FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049324> ?p ?o ?g. }

• W4328049324 abstract "The prevalence of diarrhoea remains high despite efforts by governments and NGOs to reverse trend. This study investigated the antidiarrhoeal activity and mechanism of Spondias mombin leaf fraction rich in quercetin-3-O-β-D-glucopyranoside (Q3G-RF) because of the acclaimed therapeutic efficacy. Secretory, osmotic, and infectious diarrhoea models using castor oil, magnesium sulphate, and Shigella flexneri respectively were evaluated at the doses of 100, 200, and 400 mg/kg in Wistar rats. Enteropathy was induced with castor oil and magnesium sulphate, while gastrointestinal motility was determined with charcoal meal.Findings showed no mortality after 14 days of experimental period and no significant changes in behaviour, food, and water consumption. Relative to control, Q3G-RF inhibited the three models of diarrhoea, enteropathy, and gastrointestinal motility; bacterial colonies were reduced by Q3G-RF, while it improved the relative body weight of the animals. Q3G-RF also increased the intestinal concentration/activity of glucose, total protein, and Na+-K+ ATPase but reduced the concentration of TNF-α, PGE2, IL-1β, nitric oxide, Na+, K+, and Cl- in the diarrhoeal models. The intestinal fluid level of K+, Na+, and Cl- was significantly decreased by Q3G-RF in the enteropathy model. Length of the small intestine in the motility model was also increased by Q3G-RF, while peristaltic index and inhibition of peristalsis were reduced.Overall, quercetin-3-O-β-D-glucopyranoside from Spondias mombin leaves demonstrated efficacy against infectious, secretory, and osmotic form of diarrhoeal and further justified its traditional use in the treatment of diarrhoea due to its antimotility, antisecretory, and antimicrobial properties by mechanism related to enhanced Na+-K+ ATPase, repressed nitric oxide, and suppressed prostaglandins." @default.
• W4328049324 created "2023-03-22" @default.
• W4328049324 creator A5050376647 @default.
• W4328049324 creator A5052175205 @default.
• W4328049324 creator A5080756146 @default.
• W4328049324 date "2023-03-21" @default.
• W4328049324 modified "2023-10-01" @default.
• W4328049324 title "Quercetin-3-O-β-D-glucopyranoside-rich fraction demonstrated efficacy against infectious, secretory, and osmotic models of diarrhoeal rats" @default.
• W4328049324 cites W1506043065 @default.
• W4328049324 cites W1518561899 @default.
• W4328049324 cites W1593672322 @default.
• W4328049324 cites W1595501317 @default.
• W4328049324 cites W1981754587 @default.
• W4328049324 cites W1984756160 @default.
• W4328049324 cites W1986486598 @default.
• W4328049324 cites W1988914248 @default.
• W4328049324 cites W2000675841 @default.
• W4328049324 cites W2023286233 @default.
• W4328049324 cites W2026532403 @default.
• W4328049324 cites W2027707153 @default.
• W4328049324 cites W2029076251 @default.
• W4328049324 cites W2029394593 @default.
• W4328049324 cites W2032240794 @default.
• W4328049324 cites W2038455213 @default.
• W4328049324 cites W2042267700 @default.
• W4328049324 cites W2045763309 @default.
• W4328049324 cites W2049102957 @default.
• W4328049324 cites W2054295019 @default.
• W4328049324 cites W2075963448 @default.
• W4328049324 cites W2079650696 @default.
• W4328049324 cites W2095138127 @default.
• W4328049324 cites W2133041320 @default.
• W4328049324 cites W2146134790 @default.
• W4328049324 cites W2186171267 @default.
• W4328049324 cites W2337938739 @default.
• W4328049324 cites W2526612052 @default.
• W4328049324 cites W2566147975 @default.
• W4328049324 cites W2594108836 @default.
• W4328049324 cites W2594988463 @default.
• W4328049324 cites W2602209783 @default.
• W4328049324 cites W2741542929 @default.
• W4328049324 cites W2772983862 @default.
• W4328049324 cites W2791662676 @default.
• W4328049324 cites W2806467918 @default.
• W4328049324 cites W2894914680 @default.
• W4328049324 cites W2903575615 @default.
• W4328049324 cites W2945888650 @default.
• W4328049324 cites W2947426424 @default.
• W4328049324 cites W2960175274 @default.
• W4328049324 cites W2982340789 @default.
• W4328049324 cites W3006540190 @default.
• W4328049324 cites W3007324425 @default.
• W4328049324 cites W3151426337 @default.
• W4328049324 cites W3201145943 @default.
• W4328049324 cites W3213679698 @default.
• W4328049324 cites W4233662388 @default.
• W4328049324 cites W4244319697 @default.
• W4328049324 cites W4292316612 @default.
• W4328049324 cites W4315753010 @default.
• W4328049324 doi "https://doi.org/10.1186/s43141-023-00489-7" @default.
• W4328049324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36943553" @default.
• W4328049324 hasPublicationYear "2023" @default.
• W4328049324 type Work @default.
• W4328049324 citedByCount "0" @default.
• W4328049324 crossrefType "journal-article" @default.
• W4328049324 hasAuthorship W4328049324A5050376647 @default.
• W4328049324 hasAuthorship W4328049324A5052175205 @default.
• W4328049324 hasAuthorship W4328049324A5080756146 @default.
• W4328049324 hasBestOaLocation W43280493241 @default.
• W4328049324 hasConcept C126322002 @default.
• W4328049324 hasConcept C185592680 @default.
• W4328049324 hasConcept C2777573665 @default.
• W4328049324 hasConcept C2778229996 @default.
• W4328049324 hasConcept C2778814440 @default.
• W4328049324 hasConcept C2779802037 @default.
• W4328049324 hasConcept C31903555 @default.
• W4328049324 hasConcept C54355233 @default.
• W4328049324 hasConcept C55493867 @default.
• W4328049324 hasConcept C58207958 @default.
• W4328049324 hasConcept C71924100 @default.
• W4328049324 hasConcept C86803240 @default.
• W4328049324 hasConcept C89423630 @default.
• W4328049324 hasConceptScore W4328049324C126322002 @default.
• W4328049324 hasConceptScore W4328049324C185592680 @default.
• W4328049324 hasConceptScore W4328049324C2777573665 @default.
• W4328049324 hasConceptScore W4328049324C2778229996 @default.
• W4328049324 hasConceptScore W4328049324C2778814440 @default.
• W4328049324 hasConceptScore W4328049324C2779802037 @default.
• W4328049324 hasConceptScore W4328049324C31903555 @default.
• W4328049324 hasConceptScore W4328049324C54355233 @default.
• W4328049324 hasConceptScore W4328049324C55493867 @default.
• W4328049324 hasConceptScore W4328049324C58207958 @default.
• W4328049324 hasConceptScore W4328049324C71924100 @default.
• W4328049324 hasConceptScore W4328049324C86803240 @default.
• W4328049324 hasConceptScore W4328049324C89423630 @default.
• W4328049324 hasIssue "1" @default.
• W4328049324 hasLocation W43280493241 @default.
• W4328049324 hasLocation W43280493242 @default.
• W4328049324 hasLocation W43280493243 @default.
• W4328049324 hasOpenAccess W4328049324 @default.

• next