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- W4328049345 abstract "Aryl hydrocarbon receptor (AhR) enhances insect resistance to insecticides by regulating the detoxification network. Our previous studies have confirmed that overexpressions of cytochrome P450 monooxygenases (P450s) and glutathione S-transferases (GSTs) are involved in lambda-cyhalothrin resistance in Cydia pomonella. Here, we report that CpAhR regulates the expression of GST and P450 genes, thus conferring resistance. Expression patterns indicated that the expression of CpAhR was highly induced by lambda-cyhalothrin exposure and upregulated in a lambda-cyhalothrin-resistant population. RNA interference (RNAi) of CpAhR decreases the expression of key resistance-related genes (CpGSTe3, CpCYP9A121, and CpCYP9A122) and the activity of the GST enzyme, reducing the tolerance to lambda-cyhalothrin. Furthermore, β-naphthoflavone, a novel agonist of AhR, was first proven to be effective in increasing CpAhR expression and larval tolerance to lambda-cyhalothrin. These results demonstrate that CpAhR regulates the expression of key detoxifying genes and GST activity, resulting in the development of resistance to lambda-cyhalothrin in C. pomonella." @default.
- W4328049345 created "2023-03-22" @default.
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- W4328049345 date "2023-03-21" @default.
- W4328049345 modified "2023-10-18" @default.
- W4328049345 title "Transcription Factor AhR Regulates Glutathione <i>S</i>-Transferases Conferring Resistance to <i>lambda</i>-Cyhalothrin in <i>Cydia pomonella</i>" @default.
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- W4328049345 doi "https://doi.org/10.1021/acs.jafc.3c00002" @default.
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