FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049356> ?p ?o ?g. }

• W4328049356 endingPage "1414" @default.
• W4328049356 startingPage "1406" @default.
• W4328049356 abstract "Background: Colorectal cancer (CRC) is one of the most common tumors globally and a leading cause of cancer-related death. In China, CRC is the third most common cancer type. Sauchinone is known to exhibit anti-tumor and anti-inflammatory activity, but its effects on CRC have not been investigated to-date Objective: To investigate the effects of Sauchinone on CRC development and metastasis and its underlying mechanism( s) of action. Methods: SW480 and HCT116 cells were treated with a range of concentrations of Sauchinone. Cell proliferation was measured using EDU assays and flow cytometry. Results: Treatment with 50 μM Sauchinone decreased the expression of MMP2 and MMP9 and downregulated PD-L1 expression (PD-1/PD-L1) leading to checkpoint inhibition. Sauchinone treatment also enhanced the cytotoxicity of SW840 and HCT116 cells co-cultured with CD8+ T cells. The overexpression of PD-L1 rescued the anti-proliferative and cytotoxic effects of Sauchinone in both types. Conclusions: We show that Sauchinone suppresses CRC cell growth through the downregulation of MMP2 and MM9 expression and PD-1/PD-L1 mediated checkpoint inhibition. Collectively, these data highlight the promise of Sauchinone as a future anti-CRC therapeutic." @default.
• W4328049356 created "2023-03-22" @default.
• W4328049356 creator A5019210671 @default.
• W4328049356 creator A5025341885 @default.
• W4328049356 creator A5027484990 @default.
• W4328049356 creator A5037517299 @default.
• W4328049356 creator A5075877965 @default.
• W4328049356 creator A5086131086 @default.
• W4328049356 creator A5090536716 @default.
• W4328049356 date "2023-07-10" @default.
• W4328049356 modified "2023-10-15" @default.
• W4328049356 title "Sauchinone Inhibits the Proliferation and Immune Invasion Capacity of Colorectal Cancer Cells through the Suppression of PD-L1 and MMP2/MM9" @default.
• W4328049356 cites W1601679057 @default.
• W4328049356 cites W1977000581 @default.
• W4328049356 cites W2001067765 @default.
• W4328049356 cites W2004241472 @default.
• W4328049356 cites W2018349757 @default.
• W4328049356 cites W2021065674 @default.
• W4328049356 cites W2032145559 @default.
• W4328049356 cites W2061160505 @default.
• W4328049356 cites W2063264144 @default.
• W4328049356 cites W2063532871 @default.
• W4328049356 cites W2075426577 @default.
• W4328049356 cites W2076111644 @default.
• W4328049356 cites W2078698366 @default.
• W4328049356 cites W2080660536 @default.
• W4328049356 cites W2082035524 @default.
• W4328049356 cites W2086437355 @default.
• W4328049356 cites W2107556275 @default.
• W4328049356 cites W2108855090 @default.
• W4328049356 cites W2144357848 @default.
• W4328049356 cites W2144855008 @default.
• W4328049356 cites W2154401382 @default.
• W4328049356 cites W2166573361 @default.
• W4328049356 cites W2317192801 @default.
• W4328049356 cites W2397715055 @default.
• W4328049356 cites W2510527335 @default.
• W4328049356 cites W2549202587 @default.
• W4328049356 cites W2705078637 @default.
• W4328049356 cites W2790011229 @default.
• W4328049356 cites W2894279258 @default.
• W4328049356 cites W2901513648 @default.
• W4328049356 cites W2907545453 @default.
• W4328049356 cites W2970366490 @default.
• W4328049356 cites W2999417355 @default.
• W4328049356 cites W3021780028 @default.
• W4328049356 cites W3042778505 @default.
• W4328049356 cites W3117437033 @default.
• W4328049356 cites W3128646645 @default.
• W4328049356 cites W3136328381 @default.
• W4328049356 cites W3178723556 @default.
• W4328049356 cites W3189428626 @default.
• W4328049356 cites W3205388778 @default.
• W4328049356 doi "https://doi.org/10.2174/1871520623666230320125406" @default.
• W4328049356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36941807" @default.
• W4328049356 hasPublicationYear "2023" @default.
• W4328049356 type Work @default.
• W4328049356 citedByCount "0" @default.
• W4328049356 crossrefType "journal-article" @default.
• W4328049356 hasAuthorship W4328049356A5019210671 @default.
• W4328049356 hasAuthorship W4328049356A5025341885 @default.
• W4328049356 hasAuthorship W4328049356A5027484990 @default.
• W4328049356 hasAuthorship W4328049356A5037517299 @default.
• W4328049356 hasAuthorship W4328049356A5075877965 @default.
• W4328049356 hasAuthorship W4328049356A5086131086 @default.
• W4328049356 hasAuthorship W4328049356A5090536716 @default.
• W4328049356 hasConcept C104317684 @default.
• W4328049356 hasConcept C121608353 @default.
• W4328049356 hasConcept C126322002 @default.
• W4328049356 hasConcept C127561419 @default.
• W4328049356 hasConcept C154317977 @default.
• W4328049356 hasConcept C167672396 @default.
• W4328049356 hasConcept C202751555 @default.
• W4328049356 hasConcept C203014093 @default.
• W4328049356 hasConcept C2775997469 @default.
• W4328049356 hasConcept C2777701055 @default.
• W4328049356 hasConcept C2779013556 @default.
• W4328049356 hasConcept C2780699576 @default.
• W4328049356 hasConcept C2781053074 @default.
• W4328049356 hasConcept C502942594 @default.
• W4328049356 hasConcept C526805850 @default.
• W4328049356 hasConcept C553184892 @default.
• W4328049356 hasConcept C55493867 @default.
• W4328049356 hasConcept C71924100 @default.
• W4328049356 hasConcept C86803240 @default.
• W4328049356 hasConcept C8891405 @default.
• W4328049356 hasConceptScore W4328049356C104317684 @default.
• W4328049356 hasConceptScore W4328049356C121608353 @default.
• W4328049356 hasConceptScore W4328049356C126322002 @default.
• W4328049356 hasConceptScore W4328049356C127561419 @default.
• W4328049356 hasConceptScore W4328049356C154317977 @default.
• W4328049356 hasConceptScore W4328049356C167672396 @default.
• W4328049356 hasConceptScore W4328049356C202751555 @default.
• W4328049356 hasConceptScore W4328049356C203014093 @default.
• W4328049356 hasConceptScore W4328049356C2775997469 @default.
• W4328049356 hasConceptScore W4328049356C2777701055 @default.
• W4328049356 hasConceptScore W4328049356C2779013556 @default.
• W4328049356 hasConceptScore W4328049356C2780699576 @default.

• next