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- W4328049395 endingPage "6164" @default.
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- W4328049395 abstract "The selective removal of misfolded, aggregated, or aberrantly overexpressed protein plays an essential role in maintaining protein-dominated biological processes. In parallel, the precise knockout of abnormal proteins is inseparable from the accurate identification of proteins within complex environments. Guided by these precepts, small molecules, or antibodies, are commonly used as protein recognition tools for developing targeted protein degradation (TPD) technology. Indeed, TPD has shown tremendous prospects in chronic diseases, rare diseases, cancer research, and other fields. Meanwhile, aptamers are short RNA or DNA oligonucleotides that can bind to target proteins with high specificity and strong affinity. Accordingly, aptamers are actively used in designing and constructing TPD technology. In this perspective, we provide a brief introduction to TPD technology in its current progress, and we summarize its application challenges. Recent advances in aptamer-based TPD technology are reviewed, together with corresponding challenges and outlooks." @default.
- W4328049395 created "2023-03-22" @default.
- W4328049395 creator A5009741300 @default.
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- W4328049395 creator A5041816938 @default.
- W4328049395 creator A5046214153 @default.
- W4328049395 creator A5052049171 @default.
- W4328049395 date "2023-03-21" @default.
- W4328049395 modified "2023-10-16" @default.
- W4328049395 title "Aptamer-Based Targeted Protein Degradation" @default.
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