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- W4328049452 endingPage "3296" @default.
- W4328049452 startingPage "3278" @default.
- W4328049452 abstract "The efficacy and longevity of medical implants and devices is largely determined by the host immune response, which extends along a continuum from pro-inflammatory/pro-fibrotic to anti-inflammatory/pro-regenerative. Using a rat subcutaneous implantation model, along with histological and transcriptomics analyses, we characterized the tissue response to a collagen polymeric scaffold fabricated from polymerizable type I oligomeric collagen (Oligomer) in comparison to commercial synthetic and collagen-based products. In contrast to commercial biomaterials, no evidence of an immune-mediated foreign body reaction, fibrosis, or bioresorption was observed with Oligomer scaffolds for beyond 60 days. Oligomer scaffolds were noninflammatory, eliciting minimal innate inflammation and immune cell accumulation similar to sham surgical controls. Genes associated with Th2 and regulatory T cells were instead upregulated, implying a novel pathway to immune tolerance and regenerative remodeling for biomaterials." @default.
- W4328049452 created "2023-03-22" @default.
- W4328049452 creator A5012200892 @default.
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- W4328049452 creator A5063953835 @default.
- W4328049452 creator A5088495579 @default.
- W4328049452 date "2023-01-01" @default.
- W4328049452 modified "2023-09-30" @default.
- W4328049452 title "Engineered collagen polymeric materials create noninflammatory regenerative microenvironments that avoid classical foreign body responses" @default.
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