FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049489> ?p ?o ?g. }

• W4328049489 endingPage "881" @default.
• W4328049489 startingPage "868" @default.
• W4328049489 abstract "Intermittent access to ethanol drives persistent escalation of intake and rapid transition from moderate to compulsive-like drinking. Intermittent ethanol drinking may facilitate escalation of intake in part by altering aversion-sensitive neural substrates, such as the insular cortex (IC), thus driving greater approach toward stimuli previously treated as aversive.We conducted a series of experiments in rats to examine behavioral and neural responses associated with escalation of ethanol intake. First, taste reactivity analyses quantified the degree to which intermittent brief-access ethanol exposure (BAEE) alters sensitivity to the aversive properties of ethanol. Next, we determined whether pharmacological IC inhibition facilitated ethanol escalation. Finally, given that the IC is primary gustatory cortex, we employed psychophysical paradigms to assess whether escalation of ethanol intake induced changes in ethanol taste. These paradigms measured changes in sensitivity to the intensity of ethanol taste and whether escalation in intake shifts the salient taste quality of ethanol by measuring the degree to which the taste of ethanol generalized to a sucrose-like (sweet) or quinine-like (bitter) percept.We found a near-complete loss of aversive oromotor responses in ethanol-exposed relative to ethanol-naïve rats. Additionally, we observed significantly lower expression of ethanol-induced c-Fos expression in the posterior IC in exposed rats relative to naïve rats. Inhibition of the IC resulted in a modest, but statistically reliable increase in the acceptance of higher ethanol concentrations in naïve rats. Finally, we found no evidence of changes in the psychophysical assessment of the taste of ethanol in exposed, relative to naïve, rats.Our results demonstrate that neural activity within the IC adapts following repeated presentations of ethanol in a manner that correlates with reduced sensitivity to the aversive hedonic properties of ethanol. These data help to establish that alterations in IC activity may be driving exposure-induced escalations in ethanol intake." @default.
• W4328049489 created "2023-03-22" @default.
• W4328049489 creator A5005171359 @default.
• W4328049489 creator A5013819026 @default.
• W4328049489 creator A5018299646 @default.
• W4328049489 creator A5029664463 @default.
• W4328049489 creator A5041122275 @default.
• W4328049489 creator A5044294575 @default.
• W4328049489 creator A5056001709 @default.
• W4328049489 creator A5059188981 @default.
• W4328049489 creator A5085779888 @default.
• W4328049489 creator A5089285177 @default.
• W4328049489 date "2023-03-27" @default.
• W4328049489 modified "2023-10-17" @default.
• W4328049489 title "Escalation of alcohol intake is associated with regionally decreased insular cortex activity but not changes in taste quality" @default.
• W4328049489 cites W1766450525 @default.
• W4328049489 cites W1895471809 @default.
• W4328049489 cites W1911892451 @default.
• W4328049489 cites W1927813783 @default.
• W4328049489 cites W1963505486 @default.
• W4328049489 cites W1963841728 @default.
• W4328049489 cites W1965232467 @default.
• W4328049489 cites W1966095198 @default.
• W4328049489 cites W1973285563 @default.
• W4328049489 cites W1976397511 @default.
• W4328049489 cites W1977546136 @default.
• W4328049489 cites W1977860649 @default.
• W4328049489 cites W1984890462 @default.
• W4328049489 cites W1989575442 @default.
• W4328049489 cites W1993824460 @default.
• W4328049489 cites W2003290371 @default.
• W4328049489 cites W2007305571 @default.
• W4328049489 cites W2009607921 @default.
• W4328049489 cites W2010293453 @default.
• W4328049489 cites W2013148390 @default.
• W4328049489 cites W2024145182 @default.
• W4328049489 cites W2031678730 @default.
• W4328049489 cites W2049987138 @default.
• W4328049489 cites W2054653813 @default.
• W4328049489 cites W2066028711 @default.
• W4328049489 cites W2068129377 @default.
• W4328049489 cites W2071669964 @default.
• W4328049489 cites W2079131272 @default.
• W4328049489 cites W2087548005 @default.
• W4328049489 cites W2088129443 @default.
• W4328049489 cites W2112038105 @default.
• W4328049489 cites W2112454397 @default.
• W4328049489 cites W2121255669 @default.
• W4328049489 cites W2123138197 @default.
• W4328049489 cites W2134638178 @default.
• W4328049489 cites W2146600835 @default.
• W4328049489 cites W2161798290 @default.
• W4328049489 cites W2164912344 @default.
• W4328049489 cites W2171445381 @default.
• W4328049489 cites W2267276584 @default.
• W4328049489 cites W2282463192 @default.
• W4328049489 cites W2330839345 @default.
• W4328049489 cites W2586386435 @default.
• W4328049489 cites W2762152147 @default.
• W4328049489 cites W2762245031 @default.
• W4328049489 cites W2765667151 @default.
• W4328049489 cites W2773846035 @default.
• W4328049489 cites W2792490393 @default.
• W4328049489 cites W2891035442 @default.
• W4328049489 cites W2899021891 @default.
• W4328049489 cites W2902170611 @default.
• W4328049489 cites W2945624084 @default.
• W4328049489 cites W2969542180 @default.
• W4328049489 cites W2970067111 @default.
• W4328049489 cites W3034452604 @default.
• W4328049489 cites W3045724273 @default.
• W4328049489 cites W3122712970 @default.
• W4328049489 cites W3193182608 @default.
• W4328049489 cites W3213200189 @default.
• W4328049489 cites W4232801692 @default.
• W4328049489 cites W4252741908 @default.
• W4328049489 cites W4282931469 @default.
• W4328049489 cites W4313236856 @default.
• W4328049489 doi "https://doi.org/10.1111/acer.15060" @default.
• W4328049489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36941800" @default.
• W4328049489 hasPublicationYear "2023" @default.
• W4328049489 type Work @default.
• W4328049489 citedByCount "1" @default.
• W4328049489 countsByYear W43280494892023 @default.
• W4328049489 crossrefType "journal-article" @default.
• W4328049489 hasAuthorship W4328049489A5005171359 @default.
• W4328049489 hasAuthorship W4328049489A5013819026 @default.
• W4328049489 hasAuthorship W4328049489A5018299646 @default.
• W4328049489 hasAuthorship W4328049489A5029664463 @default.
• W4328049489 hasAuthorship W4328049489A5041122275 @default.
• W4328049489 hasAuthorship W4328049489A5044294575 @default.
• W4328049489 hasAuthorship W4328049489A5056001709 @default.
• W4328049489 hasAuthorship W4328049489A5059188981 @default.
• W4328049489 hasAuthorship W4328049489A5085779888 @default.
• W4328049489 hasAuthorship W4328049489A5089285177 @default.
• W4328049489 hasConcept C126322002 @default.
• W4328049489 hasConcept C134018914 @default.
• W4328049489 hasConcept C15744967 @default.

• next