FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049550> ?p ?o ?g. }

• W4328049550 endingPage "621" @default.
• W4328049550 startingPage "604" @default.
• W4328049550 abstract "Abstract In plants, microRNA (miRNA)—target interactions (MTIs) require high complementarity, a feature from which bioinformatic programs have predicted numerous and diverse targets for any given miRNA, promoting the idea of complex miRNA networks. Opposing this is a hypothesis of constrained miRNA specificity, in which functional MTIs are restricted to the few targets whose required expression output is compatible with the expression of the miRNA. To explore these opposing views, the bioinformatic pipeline Targets Ranked Using Experimental Evidence was applied to strongly conserved miRNAs to identity their high-evidence (HE) targets across species. For each miRNA family, HE targets predominantly consisted of homologs from one conserved target gene family (primary family). These primary families corresponded to the known canonical miRNA–target families, validating the approach. Very few additional HE target families were identified (secondary family), and if so, they were likely functionally related to the primary family. Many primary target families contained highly conserved nucleotide sequences flanking their miRNA-binding sites that were enriched in HE homologs across species. A number of these flanking sequences are predicted to form conserved RNA secondary structures that preferentially base pair with the miRNA-binding site, implying that these sites are highly structured. Our findings support a target landscape view that is dominated by the conserved primary target families, with a minority of either secondary target families or non-conserved targets. This is consistent with the constrained hypothesis of functional miRNA specificity, which potentially in part is being facilitated by features beyond complementarity." @default.
• W4328049550 created "2023-03-22" @default.
• W4328049550 creator A5018152109 @default.
• W4328049550 creator A5038759115 @default.
• W4328049550 date "2023-03-20" @default.
• W4328049550 modified "2023-09-27" @default.
• W4328049550 title "Target landscape of conserved plant microRNAs and the complexities of their ancient microRNA binding-sites." @default.
• W4328049550 cites W150091557 @default.
• W4328049550 cites W1543796220 @default.
• W4328049550 cites W1965917470 @default.
• W4328049550 cites W1967543716 @default.
• W4328049550 cites W1971028992 @default.
• W4328049550 cites W1982660543 @default.
• W4328049550 cites W1984820303 @default.
• W4328049550 cites W1993533777 @default.
• W4328049550 cites W1997502251 @default.
• W4328049550 cites W1998758865 @default.
• W4328049550 cites W2000970460 @default.
• W4328049550 cites W2009540277 @default.
• W4328049550 cites W2012361460 @default.
• W4328049550 cites W2012591945 @default.
• W4328049550 cites W2015105691 @default.
• W4328049550 cites W2022441904 @default.
• W4328049550 cites W2028308990 @default.
• W4328049550 cites W2030632688 @default.
• W4328049550 cites W2039531605 @default.
• W4328049550 cites W2049096796 @default.
• W4328049550 cites W2059113522 @default.
• W4328049550 cites W2064949291 @default.
• W4328049550 cites W2081728879 @default.
• W4328049550 cites W2090287641 @default.
• W4328049550 cites W2092061344 @default.
• W4328049550 cites W2099267861 @default.
• W4328049550 cites W2111272410 @default.
• W4328049550 cites W2116122104 @default.
• W4328049550 cites W2117207028 @default.
• W4328049550 cites W2120772351 @default.
• W4328049550 cites W2128034264 @default.
• W4328049550 cites W2137015675 @default.
• W4328049550 cites W2138930960 @default.
• W4328049550 cites W2139582953 @default.
• W4328049550 cites W2141292707 @default.
• W4328049550 cites W2146100687 @default.
• W4328049550 cites W2146127418 @default.
• W4328049550 cites W2146256775 @default.
• W4328049550 cites W2147790590 @default.
• W4328049550 cites W2149127266 @default.
• W4328049550 cites W2150415116 @default.
• W4328049550 cites W2153804545 @default.
• W4328049550 cites W2155801118 @default.
• W4328049550 cites W2156852055 @default.
• W4328049550 cites W2157039533 @default.
• W4328049550 cites W2158227860 @default.
• W4328049550 cites W2158266834 @default.
• W4328049550 cites W2159117141 @default.
• W4328049550 cites W2160378127 @default.
• W4328049550 cites W2162170048 @default.
• W4328049550 cites W2163705253 @default.
• W4328049550 cites W2167852161 @default.
• W4328049550 cites W2167868554 @default.
• W4328049550 cites W2169150541 @default.
• W4328049550 cites W2170561036 @default.
• W4328049550 cites W2184540117 @default.
• W4328049550 cites W2538671407 @default.
• W4328049550 cites W2588836588 @default.
• W4328049550 cites W2616747577 @default.
• W4328049550 cites W2617338364 @default.
• W4328049550 cites W2729054356 @default.
• W4328049550 cites W2771343425 @default.
• W4328049550 cites W2780713396 @default.
• W4328049550 cites W2781674199 @default.
• W4328049550 cites W2800206218 @default.
• W4328049550 cites W2898047749 @default.
• W4328049550 cites W2898440040 @default.
• W4328049550 cites W2912258142 @default.
• W4328049550 cites W2938574745 @default.
• W4328049550 cites W2949470979 @default.
• W4328049550 cites W2966478152 @default.
• W4328049550 cites W2984077639 @default.
• W4328049550 cites W2985449232 @default.
• W4328049550 cites W3041336634 @default.
• W4328049550 cites W3140139122 @default.
• W4328049550 cites W4220938398 @default.
• W4328049550 cites W4223935181 @default.
• W4328049550 cites W4292121948 @default.
• W4328049550 doi "https://doi.org/10.1093/pcp/pcad019" @default.
• W4328049550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36943747" @default.
• W4328049550 hasPublicationYear "2023" @default.
• W4328049550 type Work @default.
• W4328049550 citedByCount "0" @default.
• W4328049550 crossrefType "journal-article" @default.
• W4328049550 hasAuthorship W4328049550A5018152109 @default.
• W4328049550 hasAuthorship W4328049550A5038759115 @default.
• W4328049550 hasConcept C104317684 @default.
• W4328049550 hasConcept C145059251 @default.
• W4328049550 hasConcept C167625842 @default.
• W4328049550 hasConcept C199216141 @default.
• W4328049550 hasConcept C202269582 @default.

• next