Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049557> ?p ?o ?g. }
- W4328049557 endingPage "2861" @default.
- W4328049557 startingPage "2846" @default.
- W4328049557 abstract "Abstract BACKGROUND With no effective drugs or widely available vaccines, dengue control in Bangladesh is dependent on targeting the primary vector Aedes aegypti with insecticides and larval source management. Despite these interventions, the dengue burden is increasing in Bangladesh, and the country experienced its worst outbreak in 2019 with 101 354 hospitalized cases. This may be partially facilitated by the presence of intense insecticide resistance in vector populations. Here, we describe the intensity and mechanisms of resistance to insecticides commonly deployed against Ae. aegypti in Dhaka, Bangladesh. RESULTS Dhaka Ae. aegypti colonies exhibited high‐intensity resistance to pyrethroids. Using CDC bottle assays, we recorded 2–24% mortality (recorded at 24 h) to permethrin and 48–94% mortality to deltamethrin, at 10× the diagnostic dose. Bioassays conducted using insecticide–synergist combinations suggested that metabolic mechanisms were contributing to pyrethroid resistance, specifically multi‐function oxidases, esterases, and glutathione S‐transferases. In addition, kdr alleles were detected, with a high frequency (78–98%) of homozygotes for the V1016G mutation. A large proportion (≤ 74%) of free‐flying and resting mosquitoes from Dhaka colonies survived exposure to standard applications of pyrethroid aerosols in an experimental free‐flight room. Although that exposure affected the immediate host‐seeking behavior of Ae. aegypti , the effect was transient in surviving mosquitoes. CONCLUSION The intense resistance characterized in this study is likely compromising the operational effectiveness of pyrethroids against Ae. aegypti in Dhaka. Switching to alternative chemical classes may offer a medium‐term solution, but ultimately a more sustainable and effective approach to controlling dengue vectors is required. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry." @default.
- W4328049557 created "2023-03-22" @default.
- W4328049557 creator A5001354661 @default.
- W4328049557 creator A5018972483 @default.
- W4328049557 creator A5022807154 @default.
- W4328049557 creator A5026961668 @default.
- W4328049557 creator A5038783239 @default.
- W4328049557 creator A5042071284 @default.
- W4328049557 creator A5066933109 @default.
- W4328049557 creator A5072042222 @default.
- W4328049557 creator A5088600190 @default.
- W4328049557 date "2023-04-04" @default.
- W4328049557 modified "2023-10-09" @default.
- W4328049557 title "Insecticide resistance compromises the control of <i>Aedes aegypti</i> in Bangladesh" @default.
- W4328049557 cites W1577320795 @default.
- W4328049557 cites W1839046251 @default.
- W4328049557 cites W1967564010 @default.
- W4328049557 cites W1971837596 @default.
- W4328049557 cites W1982038156 @default.
- W4328049557 cites W1982337727 @default.
- W4328049557 cites W2000414525 @default.
- W4328049557 cites W2000472363 @default.
- W4328049557 cites W2014140538 @default.
- W4328049557 cites W2014904562 @default.
- W4328049557 cites W2025406220 @default.
- W4328049557 cites W2030098010 @default.
- W4328049557 cites W2033779032 @default.
- W4328049557 cites W2051157460 @default.
- W4328049557 cites W2055043387 @default.
- W4328049557 cites W2064289452 @default.
- W4328049557 cites W2085913519 @default.
- W4328049557 cites W2101023957 @default.
- W4328049557 cites W2106675599 @default.
- W4328049557 cites W2113275974 @default.
- W4328049557 cites W2114016494 @default.
- W4328049557 cites W2121012505 @default.
- W4328049557 cites W2125971291 @default.
- W4328049557 cites W2131222241 @default.
- W4328049557 cites W2135547884 @default.
- W4328049557 cites W2149510454 @default.
- W4328049557 cites W2159008002 @default.
- W4328049557 cites W2165659594 @default.
- W4328049557 cites W2168546972 @default.
- W4328049557 cites W2318680607 @default.
- W4328049557 cites W2473014184 @default.
- W4328049557 cites W2490582792 @default.
- W4328049557 cites W2542372422 @default.
- W4328049557 cites W2568328160 @default.
- W4328049557 cites W2586736080 @default.
- W4328049557 cites W259699981 @default.
- W4328049557 cites W2603430634 @default.
- W4328049557 cites W2738161666 @default.
- W4328049557 cites W2754574174 @default.
- W4328049557 cites W2795976971 @default.
- W4328049557 cites W2801209832 @default.
- W4328049557 cites W2805071219 @default.
- W4328049557 cites W2805254860 @default.
- W4328049557 cites W2806462022 @default.
- W4328049557 cites W2808921002 @default.
- W4328049557 cites W2886169094 @default.
- W4328049557 cites W2903240424 @default.
- W4328049557 cites W2914740200 @default.
- W4328049557 cites W2917389701 @default.
- W4328049557 cites W2919574247 @default.
- W4328049557 cites W2940111722 @default.
- W4328049557 cites W2979519051 @default.
- W4328049557 cites W3001660283 @default.
- W4328049557 cites W3004974563 @default.
- W4328049557 cites W3023109461 @default.
- W4328049557 cites W3027771978 @default.
- W4328049557 cites W3043301065 @default.
- W4328049557 cites W3045365581 @default.
- W4328049557 cites W3048759572 @default.
- W4328049557 cites W3097693847 @default.
- W4328049557 cites W3112115156 @default.
- W4328049557 cites W3122084850 @default.
- W4328049557 cites W3127418643 @default.
- W4328049557 cites W3133028284 @default.
- W4328049557 cites W3145511690 @default.
- W4328049557 cites W3154818635 @default.
- W4328049557 cites W3159339357 @default.
- W4328049557 cites W3166683936 @default.
- W4328049557 cites W3202405803 @default.
- W4328049557 cites W4280507523 @default.
- W4328049557 cites W883172254 @default.
- W4328049557 doi "https://doi.org/10.1002/ps.7462" @default.
- W4328049557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36942761" @default.
- W4328049557 hasPublicationYear "2023" @default.
- W4328049557 type Work @default.
- W4328049557 citedByCount "0" @default.
- W4328049557 crossrefType "journal-article" @default.
- W4328049557 hasAuthorship W4328049557A5001354661 @default.
- W4328049557 hasAuthorship W4328049557A5018972483 @default.
- W4328049557 hasAuthorship W4328049557A5022807154 @default.
- W4328049557 hasAuthorship W4328049557A5026961668 @default.
- W4328049557 hasAuthorship W4328049557A5038783239 @default.
- W4328049557 hasAuthorship W4328049557A5042071284 @default.
- W4328049557 hasAuthorship W4328049557A5066933109 @default.