Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049588> ?p ?o ?g. }
- W4328049588 abstract "Virtually all living cells are encased in glycans. They perform key cellular functions such as immunomodulation and cell–cell recognition. Yet, how their composition and configuration affect their functions remains enigmatic. Here, we constructed isogenic capsule-switch mutants harboring 84 types of capsular polysaccharides (CPSs) in Streptococcus pneumoniae . This collection enables us to systematically measure the affinity of structurally related CPSs to primary human nasal and bronchial epithelial cells. Contrary to the paradigm, the surface charge does not appreciably affect epithelial cell binding. Factors that affect adhesion to respiratory cells include the number of rhamnose residues and the presence of human-like glycomotifs in CPS. Besides, pneumococcal colonization stimulated the production of interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), and monocyte chemoattractantprotein-1 (MCP-1) in nasal epithelial cells, which also appears to be dependent on the serotype. Together, our results reveal glycomotifs of surface polysaccharides that are likely to be important for colonization and survival in the human airway." @default.
- W4328049588 created "2023-03-22" @default.
- W4328049588 creator A5002339848 @default.
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- W4328049588 creator A5088941032 @default.
- W4328049588 date "2023-03-21" @default.
- W4328049588 modified "2023-10-03" @default.
- W4328049588 title "Influence of glycan structure on the colonization of <i>Streptococcus pneumoniae</i> on human respiratory epithelial cells" @default.
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