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- W4328049767 abstract "Human papilloma virus (HPV)-related tonsil cancer is associated with favorable outcomes.The purpose of this study was to define factors affecting distant metastasis in patients with surgically treated HPV-positive tonsil cancer.The present study enrolled 76 patients diagnosed with HPV-positive tonsil cancer who underwent primary surgery between January 2010 and December 2021.Twelve (15.7%) patients experienced a distant failure with a median follow-up time of 43 months. Sites of distant metastasis included the lung (n = 10), liver (n = 1), and brain (n = 1). Upon multivariate analysis, an advanced T stage (odds ratio [OR]: 13.94, 95% confidence interval [CI]: 1.29-149.863, p = 0.003) and margin involvement (OR: 5.96, 95% CI: 1.33-26.76, p = 0.02) were independent predictors of distant metastases. The five-year disease-specific survival for the entire cohort was 85%. The multivariate analysis confirmed that distant metastasis (hazard ratio [HR]: 12.688, 95% CI: 3.424-47.016; p < 0.001) and margin involvement (HR: 6.243; 95% CI: 1.681-23.191; p = 0.006) were significant factors associated with the five-year disease-specific survival.HPV-positive tonsil cancer patients with an advanced T stage and a positive surgical margin have a substantial risk of distant metastases. Distant metastasis and margin involvement are factors that affect their survival." @default.
- W4328049767 created "2023-03-22" @default.
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- W4328049767 date "2023-03-21" @default.
- W4328049767 modified "2023-09-26" @default.
- W4328049767 title "Predictive factors of distant metastasis in surgically treated HPV-positive tonsil cancer" @default.
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- W4328049767 doi "https://doi.org/10.1371/journal.pone.0283368" @default.
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