FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049785> ?p ?o ?g. }

• W4328049785 endingPage "916" @default.
• W4328049785 startingPage "907" @default.
• W4328049785 abstract "Background Systemic lupus erythematosus (SLE) is a disorder with a complex immunopathogenesis. It is well known that the disease begins with immunological alterations and autoantibody appearance in the serum years before clinical onset. As SLE has a strong tendency to familial aggregation, first-degree relatives (FDRs) constitute a group at elevated risk. The current understanding is that external risk factors trigger underlying immune dysregulations, leading to overt disease in those with elevated genetic risk. Objective This cross-sectional study investigates the degree to which clinical features, external risk factors, and immunological profiles differ in SLE FDRs from healthy individuals and SLE patientts. Methods Three groups were studied: Lupus patient FDRs (n = 56), healthy controls (n = 20), and SLE patients (n = 20). FDRs and healthy participants completed a detailed clinical questionnaire that included questions regarding smoking and estrogen drug history. All participants were tested for the presence of the following antinuclear autoantibodies (ANAs) against: nRNP/Sm, Sm, Ro60, Ro-52, La, Scl-70, PM-Scl, PM- Scl, Jo-1, CENP B, PCNA, dsDNA, nucleosomes, histones, RibP, AMA M2, DFS70, and eight soluble cytokines, including transforming growth factor-β (TGF-β), vitamin D levels, and antibodies against Epstein-Barr virus (EBV). Results Compared with the healthy controls, FDRs had higher titers of ANA, more specific staining immunofluorescent patterns, and more autoantibody specificities. Furthermore, FDRs differed significantly in their TGF-β levels from the other two groups. In FDRs, some clinical features (hair loss, skin, and oral ulcer-like lesions) were associated with higher ANA titers and some (oral ulcer-like lesions) with the anti-Ro60-specific antibody. Interestingly, there was an association between ANA titers and levels of antibodies against EBV only in the FDR group. Conclusion First-degree relatives display unique clinical and immunological profiles, placing them between healthy individuals and SLE patients, with a balance between compensated immune dysregulation and disease-developing potential. A possible association between ANA titer and the number of clinical complaints is observed, which needs to be confirmed in more extensive studies." @default.
• W4328049785 created "2023-03-22" @default.
• W4328049785 creator A5016611722 @default.
• W4328049785 creator A5026201175 @default.
• W4328049785 creator A5037407922 @default.
• W4328049785 creator A5041634959 @default.
• W4328049785 creator A5064804335 @default.
• W4328049785 creator A5071280967 @default.
• W4328049785 creator A5091719635 @default.
• W4328049785 date "2023-03-21" @default.
• W4328049785 modified "2023-09-26" @default.
• W4328049785 title "First‐degree relatives of patients with systemic lupus erythematosus: Autoreactivity but not autoimmunity?" @default.
• W4328049785 cites W1876879632 @default.
• W4328049785 cites W1898667381 @default.
• W4328049785 cites W1971107258 @default.
• W4328049785 cites W1979198249 @default.
• W4328049785 cites W1984392812 @default.
• W4328049785 cites W1990797550 @default.
• W4328049785 cites W2003753377 @default.
• W4328049785 cites W2004257179 @default.
• W4328049785 cites W2006973273 @default.
• W4328049785 cites W2007797448 @default.
• W4328049785 cites W2013635565 @default.
• W4328049785 cites W2016644380 @default.
• W4328049785 cites W2020689018 @default.
• W4328049785 cites W2024290133 @default.
• W4328049785 cites W2025234562 @default.
• W4328049785 cites W2032691863 @default.
• W4328049785 cites W2032908953 @default.
• W4328049785 cites W2035242178 @default.
• W4328049785 cites W2041113577 @default.
• W4328049785 cites W2044381004 @default.
• W4328049785 cites W2048537061 @default.
• W4328049785 cites W2053527795 @default.
• W4328049785 cites W2064338827 @default.
• W4328049785 cites W2072651272 @default.
• W4328049785 cites W2073040237 @default.
• W4328049785 cites W2078610240 @default.
• W4328049785 cites W2080022600 @default.
• W4328049785 cites W2094604104 @default.
• W4328049785 cites W2095768834 @default.
• W4328049785 cites W2105009894 @default.
• W4328049785 cites W2108311858 @default.
• W4328049785 cites W2145978988 @default.
• W4328049785 cites W2159456028 @default.
• W4328049785 cites W2160467744 @default.
• W4328049785 cites W2302024964 @default.
• W4328049785 cites W2338263211 @default.
• W4328049785 cites W2552128067 @default.
• W4328049785 cites W2617812311 @default.
• W4328049785 cites W2618948318 @default.
• W4328049785 cites W2630573111 @default.
• W4328049785 cites W2740466018 @default.
• W4328049785 cites W2809042940 @default.
• W4328049785 cites W2898358989 @default.
• W4328049785 cites W2921652873 @default.
• W4328049785 cites W2961656032 @default.
• W4328049785 cites W2965565685 @default.
• W4328049785 cites W3014190183 @default.
• W4328049785 doi "https://doi.org/10.1111/1756-185x.14669" @default.
• W4328049785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36942901" @default.
• W4328049785 hasPublicationYear "2023" @default.
• W4328049785 type Work @default.
• W4328049785 citedByCount "0" @default.
• W4328049785 crossrefType "journal-article" @default.
• W4328049785 hasAuthorship W4328049785A5016611722 @default.
• W4328049785 hasAuthorship W4328049785A5026201175 @default.
• W4328049785 hasAuthorship W4328049785A5037407922 @default.
• W4328049785 hasAuthorship W4328049785A5041634959 @default.
• W4328049785 hasAuthorship W4328049785A5064804335 @default.
• W4328049785 hasAuthorship W4328049785A5071280967 @default.
• W4328049785 hasAuthorship W4328049785A5091719635 @default.
• W4328049785 hasConcept C126322002 @default.
• W4328049785 hasConcept C149443304 @default.
• W4328049785 hasConcept C159654299 @default.
• W4328049785 hasConcept C163764329 @default.
• W4328049785 hasConcept C203014093 @default.
• W4328049785 hasConcept C2776912625 @default.
• W4328049785 hasConcept C2779134260 @default.
• W4328049785 hasConcept C2779862289 @default.
• W4328049785 hasConcept C2780130043 @default.
• W4328049785 hasConcept C2781179581 @default.
• W4328049785 hasConcept C71924100 @default.
• W4328049785 hasConceptScore W4328049785C126322002 @default.
• W4328049785 hasConceptScore W4328049785C149443304 @default.
• W4328049785 hasConceptScore W4328049785C159654299 @default.
• W4328049785 hasConceptScore W4328049785C163764329 @default.
• W4328049785 hasConceptScore W4328049785C203014093 @default.
• W4328049785 hasConceptScore W4328049785C2776912625 @default.
• W4328049785 hasConceptScore W4328049785C2779134260 @default.
• W4328049785 hasConceptScore W4328049785C2779862289 @default.
• W4328049785 hasConceptScore W4328049785C2780130043 @default.
• W4328049785 hasConceptScore W4328049785C2781179581 @default.
• W4328049785 hasConceptScore W4328049785C71924100 @default.
• W4328049785 hasIssue "5" @default.
• W4328049785 hasLocation W43280497851 @default.
• W4328049785 hasLocation W43280497852 @default.
• W4328049785 hasOpenAccess W4328049785 @default.

• next