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- W4328049800 abstract "Abstract SARS-CoV2 infection has a poor prognosis in patients affected of idiopathic pulmonary fibrosis (IPF). Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of patients with life-threatening COVID-19 pneumonia. Because of the elevated prevalence of some auto-Abs in IPF patients, we hypothesize that the prevalence of auto-Abs neutralizing type I IFNs might be increased in the IPF population and then explained specific poor outcome after COVID-19. We screened the plasma of 247 consecutive IPF patients for the presence of auto-Abs neutralizing type I IFNs. Three patients displayed auto-Abs neutralizing type I IFNs. Among them, the only patient with documented SARS-CoV-2 infection experienced life threatening COVID-19 pneumonia. The prevalence of auto-Abs neutralizing type I IFNs in this cohort of IPF patients was not significantly different from the one of the general population. Overall, this study did not suggest any association between auto-Abs neutralizing type I IFNs and IPF." @default.
- W4328049800 created "2023-03-22" @default.
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- W4328049800 date "2023-03-20" @default.
- W4328049800 modified "2023-10-17" @default.
- W4328049800 title "No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients" @default.
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- W4328049800 doi "https://doi.org/10.1186/s12931-023-02396-4" @default.
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