Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328049805> ?p ?o ?g. }
- W4328049805 endingPage "1032" @default.
- W4328049805 startingPage "1022" @default.
- W4328049805 abstract "Glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides composed of repeating disaccharide units of uronic acid and amino sugars. The luminal surface of the bladder epithelium is coated with a GAG layer. These urothelial GAGs are thought to provide a protective barrier and serve as a potential interaction site with the urinary microbiome (urobiome). Previous studies have profiled urinary GAG composition in mixed cohorts, but the urinary GAG composition in postmenopausal women remains undefined. To investigate the relationship between GAGs and recurrent urinary tract infection (rUTI), we profiled urinary GAGs in a controlled cohort of postmenopausal women. We found that chondroitin sulfate (CS) is the major urinary GAG in postmenopausal women and that urinary CS was elevated in women with active rUTI. We also associated urinary GAGs with urobiome composition and identified bacterial species that significantly associated with urinary GAG concentration. Corynebacterium amycolatum, Porphyromonas somerae, and Staphylococcus pasteuri were positively associated with heparin sulfate or hyaluronic acid, and bacterial species associated with vaginal dysbiosis were negatively correlated with urinary CS. Altogether, this work defines changes in urinary GAG composition associated with rUTI and identifies new associations between urinary GAGs and the urobiome that may play a role in rUTI pathobiology." @default.
- W4328049805 created "2023-03-22" @default.
- W4328049805 creator A5006858052 @default.
- W4328049805 creator A5042055173 @default.
- W4328049805 creator A5042984164 @default.
- W4328049805 creator A5051646299 @default.
- W4328049805 creator A5065057086 @default.
- W4328049805 creator A5073270407 @default.
- W4328049805 creator A5075657088 @default.
- W4328049805 date "2023-03-21" @default.
- W4328049805 modified "2023-10-14" @default.
- W4328049805 title "Urinary Glycosaminoglycans Are Associated with Recurrent UTI and Urobiome Ecology in Postmenopausal Women" @default.
- W4328049805 cites W118551320 @default.
- W4328049805 cites W1909797527 @default.
- W4328049805 cites W1967961996 @default.
- W4328049805 cites W1983834376 @default.
- W4328049805 cites W1986904100 @default.
- W4328049805 cites W1997080369 @default.
- W4328049805 cites W1997638752 @default.
- W4328049805 cites W1999330037 @default.
- W4328049805 cites W2002499720 @default.
- W4328049805 cites W2027414130 @default.
- W4328049805 cites W2028367142 @default.
- W4328049805 cites W2029834429 @default.
- W4328049805 cites W2031240692 @default.
- W4328049805 cites W2041670973 @default.
- W4328049805 cites W2043533523 @default.
- W4328049805 cites W2049493406 @default.
- W4328049805 cites W2049807959 @default.
- W4328049805 cites W2076262470 @default.
- W4328049805 cites W2081023207 @default.
- W4328049805 cites W2087924999 @default.
- W4328049805 cites W2096278211 @default.
- W4328049805 cites W2096991378 @default.
- W4328049805 cites W2103488787 @default.
- W4328049805 cites W2113334534 @default.
- W4328049805 cites W2131026689 @default.
- W4328049805 cites W2133306969 @default.
- W4328049805 cites W2136752289 @default.
- W4328049805 cites W2139817382 @default.
- W4328049805 cites W2144098483 @default.
- W4328049805 cites W2162349491 @default.
- W4328049805 cites W2170181743 @default.
- W4328049805 cites W2170205663 @default.
- W4328049805 cites W2171663607 @default.
- W4328049805 cites W2259627284 @default.
- W4328049805 cites W2310269848 @default.
- W4328049805 cites W2484811418 @default.
- W4328049805 cites W2514574167 @default.
- W4328049805 cites W2574763818 @default.
- W4328049805 cites W2769458362 @default.
- W4328049805 cites W2770040643 @default.
- W4328049805 cites W2771859609 @default.
- W4328049805 cites W2792060012 @default.
- W4328049805 cites W2795926950 @default.
- W4328049805 cites W2809583627 @default.
- W4328049805 cites W2823839369 @default.
- W4328049805 cites W2885370207 @default.
- W4328049805 cites W2904805702 @default.
- W4328049805 cites W2906796312 @default.
- W4328049805 cites W2921737011 @default.
- W4328049805 cites W2943114933 @default.
- W4328049805 cites W2950285844 @default.
- W4328049805 cites W2971194364 @default.
- W4328049805 cites W3020109569 @default.
- W4328049805 cites W3111922163 @default.
- W4328049805 cites W3158099902 @default.
- W4328049805 cites W4205561401 @default.
- W4328049805 cites W4206490373 @default.
- W4328049805 cites W4207007490 @default.
- W4328049805 cites W4225134105 @default.
- W4328049805 cites W428785717 @default.
- W4328049805 cites W4298127660 @default.
- W4328049805 cites W4308425162 @default.
- W4328049805 cites W4356794 @default.
- W4328049805 cites W60421272 @default.
- W4328049805 doi "https://doi.org/10.1021/acsinfecdis.3c00027" @default.
- W4328049805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36942838" @default.
- W4328049805 hasPublicationYear "2023" @default.
- W4328049805 type Work @default.
- W4328049805 citedByCount "0" @default.
- W4328049805 crossrefType "journal-article" @default.
- W4328049805 hasAuthorship W4328049805A5006858052 @default.
- W4328049805 hasAuthorship W4328049805A5042055173 @default.
- W4328049805 hasAuthorship W4328049805A5042984164 @default.
- W4328049805 hasAuthorship W4328049805A5051646299 @default.
- W4328049805 hasAuthorship W4328049805A5065057086 @default.
- W4328049805 hasAuthorship W4328049805A5073270407 @default.
- W4328049805 hasAuthorship W4328049805A5075657088 @default.
- W4328049805 hasBestOaLocation W43280498051 @default.
- W4328049805 hasConcept C126322002 @default.
- W4328049805 hasConcept C153074725 @default.
- W4328049805 hasConcept C203014093 @default.
- W4328049805 hasConcept C42407357 @default.
- W4328049805 hasConcept C55493867 @default.
- W4328049805 hasConcept C71924100 @default.
- W4328049805 hasConcept C77411442 @default.
- W4328049805 hasConcept C86803240 @default.