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- W4328052255 endingPage "439" @default.
- W4328052255 startingPage "426" @default.
- W4328052255 abstract "Plants can be engineered to recombinantly produce high-quality proteins such as therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can be established in various settings with minimal cold-chain requirements and could thus ensure rapid and global-scale deployment of biopharmaceuticals, promoting equitable access to pharmaceuticals. State of the art plant-based engineering relies on rationally assembled genetic circuits, engineered to enable the high-throughput and rapid expression of multimeric proteins with complex post-translational modifications. In this Review, we discuss the design of expression hosts and vectors, including Nicotiana benthamiana, viral elements and transient expression vectors, for the production of biopharmaceuticals in plants. We examine engineering of post-translational modifications and highlight the plant-based expression of monoclonal antibodies and nanoparticles, such as virus-like particles and protein bodies. Techno-economic analyses suggest a cost advantage of molecular farming compared with mammalian cell-based protein production systems. However, regulatory challenges remain to be addressed to enable the widespread translation of plant-based biopharmaceuticals. Plant-based recombinant protein production has the power to ensure rapid and global-scale deployment of biopharmaceuticals. This Review discusses genetic tools and systems for the plant-based production and engineering of biopharmaceuticals, including vaccines and monoclonal antibodies." @default.
- W4328052255 created "2023-03-22" @default.
- W4328052255 creator A5003612075 @default.
- W4328052255 creator A5010661366 @default.
- W4328052255 creator A5035478507 @default.
- W4328052255 date "2023-03-21" @default.
- W4328052255 modified "2023-10-16" @default.
- W4328052255 title "Plant-based biopharmaceutical engineering" @default.
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